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Table 3 Antidiarrhoeal activity of methanolic extract and fractions against castor oil-induced diarrhoea in rats

From: Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves

Group

Dose (p.o.)

No. of faeces in 4 h

% inhibition of diarrhoea

Control

10 mL/kg, p.o.

22.5 ± 2.4

-

Loperamide

5 mg/kg, p.o.

9.5 ± 0.64*

57.78

Methanol

200 mg/kg, p.o.

15 ± 1.1*

33.33

400 mg/kg, p.o.

11.5 ± 0.09*

48.89

Ethyl acetate

200 mg/kg, p.o.

16.25 ± 1.38*

27.78

400 mg/kg, p.o.

11 ± 1.58*

51.11

Chloroform

200 mg/kg, p.o.

12 ± 1.29*

46.67

400 mg/kg, p.o.

11.25 ± 1.25*

50

Pet. ether

200 mg/kg, p.o.

15.5 ± 1.76*

31.11

 

400 mg/kg, p.o.

13.75 ± 1.38*

38.89

  1. All values are expressed as mean ± SEM (n = 5); One-way analysis of variance (ANOVA) followed by Dunnett’s test. *P < 0.05, significant compared with the control samples.