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Table 1 Mutagenic activity (mean of the number of revertants/plate ± SD) of the bacterial strains TA98, TA100, TA97a and TA102 exposed to Dipteryx alata Vogel hydroalcoholic extract, at various concentrations, with (+S9) or without (-S9) metabolic activation

From: In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract

Treatment

(mg/plate)

TA98

TA100

TA97a

TA102

 

- S9

+ S9

- S9

+ S9

- S9

+ S9

- S9

+ S9

0*

25 ± 1.0

23 ± 2.5

155 ± 5.9

207 ± 19.0

197 ± 3.5

188 ± 121

275 ± 14.5

200 ± 9.0

3.6

-

-

-

201 ± 23.5 (0.9)

227 ± 10.8* (1.2)

213 ± 9.9 (1.1)

229 ± 31.8 (0.9)

277 ± 26.9 (1.4)

4.7

25 ± 1.0 (1.0)

23 ± 2.9 (1.0)

135 ± 4.0 (0.9)

-

-

-

-

-

7.1

-

-

-

238 ± 16.5 (1.1)

203 ± 13.5 (1.0)

199 ± 3.5 (1.1)

218 ± 12.1 (0.9)

299 ± 4.6* (1.5)

9.4

40 ± 8.7* (1.6)

24 ± 2.7 (1.0)

149 ± 10.0 (0.9)

-

-

-

-

-

14.1

-

-

-

220 ± 14.8 (1.1)

201 ± 18.9(1.0)

198 ± 12.0 (1.1)

223 ± 3.5 (0.9)

303 ± 5.5* (1.5)

18.8

31 ± 4.4 (1.2)

23 ± 2.0 (1.0)

193 ± 11.7 (1.3)

-

-

-

-

-

21.2

-

-

-

190 ± 16.9 (0.9)

158 ± 31.2 (0.8)

188 ± 7.4 (1.0)

204 ± 15.0 (0.7)

291 ± 1.5 (1.4)

28.2

38 ± 2.9* (1.5)

23 ± 2.1 (1.0)

208 ± 14.0 (1.3)

-

-

-

-

-

37.6

32 ± 6.7 (1.3)

23 ± 2.1 (1.0)

226 ± 40.0* (1.5)

-

-

-

-

-

Control +

2757 ± 208.5d

879 ± 46.1a

923 ± 134.6b

1357 ± 10.6 a

1470 ± 85.9 d

1210 ± 14.5 a

1733 ± 149.7 c

1280 ± 15.3 a

  1. -: not assayed; 0*: negative control (DMSO, 100 μL/plate); Control +: positive control; a 2-Anthramine (1.25 μg/plate); b Sodium azide (1.25 μg/plate); c Mitomycin (0.5 μg/plate); d4-nitro-o-phenylenediamine (10.0 μg/plate); * p < 0.05 (ANOVA). The values in brackets represent the mutagenic index.