Skip to main content

Table 1 Effect of auraptene and lacinartin on the activity of MMP-9 and P. gingivalis collagenase

From: The plant coumarins auraptene and lacinartin as potential multifunctional therapeutic agents for treating periodontal disease

Compound

MMP-9 (% activity)

Collagenase (% activity)

None

100 ± 1

100 ± 3

Commercial inhibitor1

56 ± 1

6 ± 5

Auraptene 100 μg/ml

27 ± 1

110 ± 4

50

27 ± 1

113 ± 5

25

27 ± 3

113 ± 1

12.5

26 ± 1

107 ± 10

Lacinartin 100 μg/ml

19 ± 6

36 ± 3

50

25 ± 1

49 ± 1

25

31 ± 2

69 ± 1

12.5

26 ± 3

80 ±1

  1. 1Inhibitor of MMP-9: GM6001 (0.025 μM); inhibitor of P. gingivalis collagenase: leupeptin (1 μM).