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Table 8 Effect of DAS-77 on serum biochemical parameters in rats in the reversibility study

From: A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

Treatment Dose(mg/kg) Reversibility study
   Creatinine (μmol/L) Urea (mmol/L) Albumin (g/L) Protein (g/L) TC (mmol/L) HDL (mmol/L) LDL (mmol/L) TG (mmol/L) Glucose (mmol/L) Uric acid (μmol/L) ALP (u/L) AST (u/L) ALT (u/L) TB (μmol/L) DB (μmol/L)
Distilled water (10 ml/kg) 58.75 ± 2.95 7.68 ± 0.38 39.5 ± 1.68 83.13 ± 3.14 2.4 ± 0.25 1.59 ± 0.15 0.50 ± 0.18 0.65 ± 0.10 1.93 ± 0.36 93.74 ± 8.50 28.23 ± 5.48 65.88 ± 7.87 31.75 ± 3.08 5.75 ± 0.31 1.50 ± 0.27
DAS-77 80 60.11 ± 2.67 7.72 ± 0.36 40.89 ± 1.35 84.11 ± 3.25 2.18 ± 0.15 1.61 ± 0.15 0.24 ± 0.04 0.70 ± 0.08 2.36 ± 0.34 85.33 ± 5.54 20.11 ± 2.57 58.56 ± 5.26 26.67 ± 1.62 5.22 ± 0.15 1.44 ± 0.18
DAS-77 400 54.50 ± 1.05 7.41 ± 0.52 39.00 ± 1.60 85.38 ± 3.69 2.25 ± 0.33 1.61 ± 0.32 0.70 ± 0.16 0.68 ± 0.13 1.84 ± 0.28 97.75 ± 10.75 25.69 ± 3.09 51.50 ± 4.05 33.63 ± 2.06 5.38 ± 0.26 1.50 ± 0.38
DAS-77 2000 55.50 ± 2.05 7.12 ± 0.31 38.50 ± 1.34 84.67 ± 6.04 1.90 ± 0.24 1.10 ± 0.18 0.47 ± 0.09 0.70 ± 0.10 2.03 ± 0.48 111.20 ± 13.20 29.50 ± 3.47 74.50 ± 11.22 35.33 ± 4.55 5.17 ± 0.17 1.00 ± .00
  1. Values are mean ± S.E.M. (n = 8). p > 0.05 vs. distilled water (One-way ANOVA followed by Dunnett’s posttest).
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