Skip to main content

Table 13 Effect of DAS-77 on antioxidant enzymes in rat kidney in the main study

From: A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

Treatment

Dose (mg/kg)

Main study

Ā Ā 

GSH (nm/mg)

SOD (u/mg)

CAT

(u/mg)

Peroxidase

(u/mg)

MDA (nm/mg)

Protein (mg)

Distilled water

(10 ml/kg)

1.69ā€‰Ā±ā€‰0.15

3.41ā€‰Ā±ā€‰0.73

17.66ā€‰Ā±ā€‰5.22

1.26ā€‰Ā±ā€‰0.34

0.27ā€‰Ā±ā€‰0.08

28.94ā€‰Ā±ā€‰5.64

DAS-77

80

2.76ā€‰Ā±ā€‰0.83

12.31ā€‰Ā±ā€‰3.01

58.21ā€‰Ā±ā€‰13.80**

3.96ā€‰Ā±ā€‰0.94

0.11ā€‰Ā±ā€‰0.03*

50.22ā€‰Ā±ā€‰10.34

DAS-77

400

2.12ā€‰Ā±ā€‰0.21

7.69ā€‰Ā±ā€‰0.53

35.46ā€‰Ā±ā€‰2.43

2.32ā€‰Ā±ā€‰0.15

0.07ā€‰Ā±ā€‰0.02**

51.13ā€‰Ā±ā€‰3.57

DAS-77

2000

2.17ā€‰Ā±ā€‰0.18

9.63ā€‰Ā±ā€‰1.03

44.41ā€‰Ā±ā€‰4.75*

3.02ā€‰Ā±ā€‰0.32

0.13ā€‰Ā±ā€‰0.03*

35.22ā€‰Ā±ā€‰2.57

  1. Values are meanā€‰Ā±ā€‰S.E.M. (nā€‰=ā€‰5). * pā€‰<ā€‰0.05, ** pā€‰<ā€‰0.01 vs. distilled water (One-way ANOVA followed by Dunnettā€™s posttest).