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Table 11 Effect of DAS-77 on antioxidant enzymes in rat liver in the main study

From: A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

Treatment

Dose (mg/kg)

Main study

Ā Ā 

GSH (nm/mg)

SOD (u/mg)

CAT

(u/mg)

Peroxidase (u/mg)

MDA (nm/mg)

Protein

(mg)

Distilled water

(10 ml/kg)

1.78ā€‰Ā±ā€‰0.40

4.25ā€‰Ā±ā€‰1.31

19.62ā€‰Ā±ā€‰6.04

1.27ā€‰Ā±ā€‰0.39

0.11ā€‰Ā±ā€‰0.05

52.68ā€‰Ā±ā€‰6.14

DAS-77

80

1.75ā€‰Ā±ā€‰0.17

6.65ā€‰Ā±ā€‰0.39

30.65ā€‰Ā±ā€‰1.81

2.08ā€‰Ā±ā€‰0.12

0.04ā€‰Ā±ā€‰0.00

61.64ā€‰Ā±ā€‰6.92

DAS-77

400

2.07ā€‰Ā±ā€‰0.15

5.59ā€‰Ā±ā€‰1.03

25.76ā€‰Ā±ā€‰4.74

1.75ā€‰Ā±ā€‰0.32

0.11ā€‰Ā±ā€‰0.03

43.80ā€‰Ā±ā€‰5.34

DAS-77

2000

2.03ā€‰Ā±ā€‰0.26

6.62ā€‰Ā±ā€‰1.05

30.49ā€‰Ā±ā€‰4.81

2.08ā€‰Ā±ā€‰0.33

0.11ā€‰Ā±ā€‰0.02

47.08ā€‰Ā±ā€‰4.04

  1. Values are meanā€‰Ā±ā€‰S.E.M. (nā€‰=ā€‰5). pā€‰>ā€‰0.05 vs. distilled water (One-way ANOVA followed by Dunnettā€™s posttest).