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Table 1 Effect of roots bark extract of C. sieberiana on mucosal PGE 2 and 6-keto PGF 1α levels and serum sPLA 2 activity in guinea pigs

From: Antioxidant and gastric cytoprotective prostaglandins properties of Cassia sieberiana roots bark extract as an anti-ulcerogenic agent

Treatment

Dose (mg/kg)

PGE2(pg/mL) (Mean ± S.E.M)

6-keto PGF1α(pg/mL) (Mean ± S.E.M)

sPLA2activity (nmol/min/mL) (Mean ± S.E.M)

Control

vehicle

0.17 ± 0.02

2.10 ± 0.19

26.44 ± 0.69

Extract

250

0.23 ± 0.01*

2.69 ± 0.08*

20.84 ± 0.65‡

“

500

0.28 ± 0.02†

3.39 ± 0.34*

18.16 ± 0.68‡

“

750

0.31 ± 0.02‡

3.95 ± 0.19‡

10.52 ± 0.52‡

  1. * p < 0.05, statistically significant relative to control.
  2. † p < 0.01, statistically significant relative to control.
  3. ‡ p < 0.001, statistically significant relative to control.