Table 1 Effect of VBME at 100, 200 and 300mg/kg i.p. in yeast induced pyrexia
From: Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant
Treatment | Dosemg/kg | Rectal temperature (°C) | ||||||
|---|---|---|---|---|---|---|---|---|
After administration of drug | ||||||||
Normal (A) | after 24h (B) | 1h (C1) | 2h (C2) | 3h (C3) | 4h (C4) | 5h (C5) | ||
Saline | 10mL | 36.66 ± 0.11 | 38.92 ± 0.34 | 38.82 ± 0.21 | 38.78 ± 0.11 | 38.68 ± 0.20 | 38. 68 ± 0.20 | 38.72 ± 0.15 |
Paracetamol | 150mg | 37.08 ± 0.08 | 39.46 ± 0.04 | 38.20** ± 0.01 | 37.80** ± 0.03 | 37.30** ± 0.02 | 37.35 ** ± 0.28 | 37.38** ± 0.04 |
VBME | 100mg | 37.06 ± 0.02 | 39.70 ± 0.43 | 39.44 ± 0.22 | 38.98* ± 0.22 | 38.04** ± 0.11 | 38.16** ± 0.12 | 38.22** ± 0.11 |
|  | 200 | 37.00 ± 0.14 | 39.00 ± 0.11 | 38.68 ± 0.02 | 38.40*s ± 0.25 | 37.72** ± 0.45 | 37.80** ± 0.11 | 37.85 ± 0.41 |
|  | 300 | 37.02 ± 0.12 | 39.84 ± 0.20 | 39.30 ± 0.31 | 38.70* ± 0.12 | 37.64** ± 0.44 | 37.74** ± 0.10 | 37.80** ± 0.23 |