Glucose tolerance tests of sham operated control (SHAM) and ovariectomized (OVX) rats treated with or without C. comosa hexane extract or compound 049. Animals are as described in legend of Figure 2. Glucose (A) and insulin (B) responses; area under the curve (AUC) for glucose (C) and insulin (D); glucose-insulin (G-I) index (E). G-I index is the product of glucose AUC and insulin AUC for each individual animal. Values are reported as the mean ± SE for 7-8 animals/group. *P < 0.05 vs. SHAM group; † P < 0.05 vs. OVX group; §P < 0.05 vs. all other groups.