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Table 3 Hematological values of animals treated with SST for 4 weeks

From: Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague–Dawley rats

Dose (mg/kg/day)

0

500

1000

2000

Male rat

    

WBC (103/μL)

11.05 ± 2.35a

12.76 ± 1.78

12.68 ± 3.36

9.14 ± 2.40

Reticulocyte (%)

2.7 ± 0.42

2.7 ± 0.20

3.0 ± 0.73

2.3 ± 0.23

Neutrophils (%)

9.18 ± 2.34

11.28 ± 3.40

10.32 ± 2.35

14.60 ± 2.78*

Lymphocytes (%)

86.5 ± 3.26

81.9 ± 3.25

84.6 ± 2.67

80.1 ± 3.62*

Eosinophils (%)

0.8 ± 0.40

0.6 ± 0.09

0.6 ± 0.22

0.5 ± 0.12

Monocytes (%)

2.0 ± 0.59

2.7 ± 0.66

2.6 ± 0.63

2.6 ± 0.56

Basophils (%)

0.8 ± 0.20

1.1 ± 0.22

1.0 ± 0.21

1.3 ± 0.35

Large unstained cells (%)

0.7 ± 0.24

2.4 ± 2.97

0.9 ± 0.16

1.0 ± 0.34

RBC (106/μL)

8.04 ± 0.16

8.33 ± 0.43

8.15 ± 0.38

8.22 ± 0.55

Hemoglobin (g/dl)

15.8 ± 0.51

16.2 ± 0.58

16.1 ± 0.52

15.8 ± 0.49

Hematocrit (%)

47.7 ± 2.12

48.3 ± 1.98

48.1 ± 1.75

48.0 ± 1.76

MCV (fL)

59.2 ± 1.64

58.1 ± 1.68

59.0 ± 1.34

58.5 ± 1.79

MCH (pg)

19.6 ± 0.32

19.4 ± 0.61

19.8 ± 0.38

19.3 ± 0.75

MCHC (g/dl)

33.1 ± 0.37

33.5 ± 0.73

33.5 ± 0.44

32.9 ± 0.31

Platelet (103/μL)

1305 ± 225

1164 ± 40

1198 ± 67

1178 ± 66

PT (sec)

17.5 ± 0.86

17.2 ± 0.45

16.5 ± 0.87

16.7 ± 0.62

APTT (sec)

16.3 ± 0.80

16.7 ± 0.80

15.4 ± 1.11

16.3 ± 0.49

Female rat

    

WBC (103/μL)

8.07 ± 1.25

8.17 ± 2.38

8.27 ± 1.09

6.75 ± 0.56

Reticulocyte (%)

2.2 ± 0.38

2.7 ± 0.39

2.4 ± 0.58

2.5 ± 0.55

Neutrophils (%)

13.12 ± 6.54

15.92 ± 7.16

15.58 ± 5.63

13.20 ± 3.05

Lymphocytes (%)

81.6 ± 6.97

78.6 ± 7.19

79.2 ± 5.09

82.7 ± 2.81

Eosinophils (%)

1.0 ± 0.15

1.3 ± 0.38

1.1 ± 0.15

0.8 ± 0.17

Monocytes (%)

2.2 ± 0.86

2.6 ± 0.40

2.4 ± 0.61

1.7 ± 0.35

Basophils (%)

0.9 ± 0.21

0.8 ± 0.25

0.7 ± 0.13

0.9 ± 0.13

Large unstained cells (%)

1.2 ± 0.42

0.9 ± 0.23

1.0 ± 0.08

0.8 ± 0.26

RBC (106/μL)

8.24 ± 0.33

8.28 ± 0.16

8.18 ± 0.20

8.14 ± 0.13

Hemoglobin (g/dl)

15.9 ± 0.55

15.7 ± 0.44

16.0 ± 0.13

15.7 ± 0.19

Hematocrit (%)

46.4 ± 1.62

46.4 ± 1.06

47.0 ± 0.43

46.2 ± 0.73

MCV (fL)

56.4 ± 0.88

56.0 ± 1.67

57.5 ± 1.25

56.8 ± 0.49

MCH (pg)

19.3 ± 0.43

19.0 ± 0.54

19.6 ± 0.50

19.4 ± 0.35

MCHC (g/dl)

34.3 ± 0.28

33.9 ± 0.38

34.1 ± 0.40

34.1 ± 0.49

Platelet (103/μL)

1242 ± 76

1595 ± 430

1161 ± 100

1132 ± 32

PT (sec)

17.6 ± 0.43

18.1 ± 0.26

17.6 ± 0.59

18.3 ± 0.73

APTT (sec)

13.9 ± 0.39

15.4 ± 0.86

14.3 ± 1.10

14.8 ± 0.75

  1. APTT, activated partial thromboplastin time; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PT, prothrombin time.
  2. a Values are presented as mean ± SD.
  3. * Indicate a significant difference at P < 0.05 level, when compared with the vehicle control group.