Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
---|---|---|---|---|
Male rat | ||||
WBC (103/μL) | 11.05 ± 2.35a | 12.76 ± 1.78 | 12.68 ± 3.36 | 9.14 ± 2.40 |
Reticulocyte (%) | 2.7 ± 0.42 | 2.7 ± 0.20 | 3.0 ± 0.73 | 2.3 ± 0.23 |
Neutrophils (%) | 9.18 ± 2.34 | 11.28 ± 3.40 | 10.32 ± 2.35 | 14.60 ± 2.78* |
Lymphocytes (%) | 86.5 ± 3.26 | 81.9 ± 3.25 | 84.6 ± 2.67 | 80.1 ± 3.62* |
Eosinophils (%) | 0.8 ± 0.40 | 0.6 ± 0.09 | 0.6 ± 0.22 | 0.5 ± 0.12 |
Monocytes (%) | 2.0 ± 0.59 | 2.7 ± 0.66 | 2.6 ± 0.63 | 2.6 ± 0.56 |
Basophils (%) | 0.8 ± 0.20 | 1.1 ± 0.22 | 1.0 ± 0.21 | 1.3 ± 0.35 |
Large unstained cells (%) | 0.7 ± 0.24 | 2.4 ± 2.97 | 0.9 ± 0.16 | 1.0 ± 0.34 |
RBC (106/μL) | 8.04 ± 0.16 | 8.33 ± 0.43 | 8.15 ± 0.38 | 8.22 ± 0.55 |
Hemoglobin (g/dl) | 15.8 ± 0.51 | 16.2 ± 0.58 | 16.1 ± 0.52 | 15.8 ± 0.49 |
Hematocrit (%) | 47.7 ± 2.12 | 48.3 ± 1.98 | 48.1 ± 1.75 | 48.0 ± 1.76 |
MCV (fL) | 59.2 ± 1.64 | 58.1 ± 1.68 | 59.0 ± 1.34 | 58.5 ± 1.79 |
MCH (pg) | 19.6 ± 0.32 | 19.4 ± 0.61 | 19.8 ± 0.38 | 19.3 ± 0.75 |
MCHC (g/dl) | 33.1 ± 0.37 | 33.5 ± 0.73 | 33.5 ± 0.44 | 32.9 ± 0.31 |
Platelet (103/μL) | 1305 ± 225 | 1164 ± 40 | 1198 ± 67 | 1178 ± 66 |
PT (sec) | 17.5 ± 0.86 | 17.2 ± 0.45 | 16.5 ± 0.87 | 16.7 ± 0.62 |
APTT (sec) | 16.3 ± 0.80 | 16.7 ± 0.80 | 15.4 ± 1.11 | 16.3 ± 0.49 |
Female rat | ||||
WBC (103/μL) | 8.07 ± 1.25 | 8.17 ± 2.38 | 8.27 ± 1.09 | 6.75 ± 0.56 |
Reticulocyte (%) | 2.2 ± 0.38 | 2.7 ± 0.39 | 2.4 ± 0.58 | 2.5 ± 0.55 |
Neutrophils (%) | 13.12 ± 6.54 | 15.92 ± 7.16 | 15.58 ± 5.63 | 13.20 ± 3.05 |
Lymphocytes (%) | 81.6 ± 6.97 | 78.6 ± 7.19 | 79.2 ± 5.09 | 82.7 ± 2.81 |
Eosinophils (%) | 1.0 ± 0.15 | 1.3 ± 0.38 | 1.1 ± 0.15 | 0.8 ± 0.17 |
Monocytes (%) | 2.2 ± 0.86 | 2.6 ± 0.40 | 2.4 ± 0.61 | 1.7 ± 0.35 |
Basophils (%) | 0.9 ± 0.21 | 0.8 ± 0.25 | 0.7 ± 0.13 | 0.9 ± 0.13 |
Large unstained cells (%) | 1.2 ± 0.42 | 0.9 ± 0.23 | 1.0 ± 0.08 | 0.8 ± 0.26 |
RBC (106/μL) | 8.24 ± 0.33 | 8.28 ± 0.16 | 8.18 ± 0.20 | 8.14 ± 0.13 |
Hemoglobin (g/dl) | 15.9 ± 0.55 | 15.7 ± 0.44 | 16.0 ± 0.13 | 15.7 ± 0.19 |
Hematocrit (%) | 46.4 ± 1.62 | 46.4 ± 1.06 | 47.0 ± 0.43 | 46.2 ± 0.73 |
MCV (fL) | 56.4 ± 0.88 | 56.0 ± 1.67 | 57.5 ± 1.25 | 56.8 ± 0.49 |
MCH (pg) | 19.3 ± 0.43 | 19.0 ± 0.54 | 19.6 ± 0.50 | 19.4 ± 0.35 |
MCHC (g/dl) | 34.3 ± 0.28 | 33.9 ± 0.38 | 34.1 ± 0.40 | 34.1 ± 0.49 |
Platelet (103/μL) | 1242 ± 76 | 1595 ± 430 | 1161 ± 100 | 1132 ± 32 |
PT (sec) | 17.6 ± 0.43 | 18.1 ± 0.26 | 17.6 ± 0.59 | 18.3 ± 0.73 |
APTT (sec) | 13.9 ± 0.39 | 15.4 ± 0.86 | 14.3 ± 1.10 | 14.8 ± 0.75 |