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Table 4 Effects of GE on the expression of inflammatory markers in adipose tissue

From: Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet

Genes investigated ND240 HFD60 HFD120 HFD240 HFDMET
IL-6 −1.17±0.67 −1.38±0.41c −1.11±0.20d −3.27±0.92b −1.35±0.03c
CRP −2.10±0.60 0.10±0.78a −4.00±0.21b −3.40±0.87b −2.30±0.12c
MCP-1 −1.63±0.45 1.09±0.14b −2.33±0.24c −1.33±0.69d −1.20±1.10d
SAA-2 −1.55±0.66 −5.53±0.47b −5.39±0.54b −5.67±0.95b −3.82±0.77c
NF-κB −1.11±0.37 −2.30±0.29b −2.90±0.92c −2.30±0.30b −2.45±1.13b
TNF-α −3.46±0.09 1.16±0.21b −4.50±0.43c −4.11±0.37c −1.79±1.06d
  1. Results are expressed as –fold variation over the appropriate control groups; ND240 indicate fold increase over ND, normal diet control group and HFD60, HFD120, HFD240 and HFDMET indicate fold increase over HFD, high-fat diet control group. Fold variations less than one were expressed as negative numbers (e.g., a –fold variation of 0.50 is expressed as −2.00). Values expressed are means ± S.D of triplicate measurements. Statistical significance was calculated based on the mean ΔCT values by DMRT for only mice fed with high-fat diet with or without GE. For same gene with different treatment groups, means in the different rows with different alphabets (a-d) were significantly different (p<0.05).