Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet

Table 3 Effects of GE on the expression of adipokines in adipose tissue

Genes investigated	ND240	HFD60	HFD120	HFD240	HFDMET
GLUT-4	1.49±0.24	1.78±0.3b^d	2.41±0.42^b	2.05±0.32^a	1.13±0.13^c
Adiponectin	1.56±0.15	0.81±0.37^c	1.13±0.62^b	1.68±0.30^a	1.66±0.24^a
RBP-4	0.10±0.13	−1.20±0.16^b	−1.30±0.44^b	−1.63±0.33^a	−1.50±0.17^a

Results are expressed as –fold variation over the appropriate control groups; ND240 indicate fold increase over ND, normal diet control group and HFD60, HFD120, HFD240 and HFDMET indicate fold increase over HFD, high-fat diet control group. Fold variations less than one were expressed as negative numbers (e.g., a –fold variation of 0.50 is expressed as −2.00). Values expressed are means ± S.D of triplicate measurements. Statistical significance was calculated based on the mean ΔCT values by DMRT for only mice fed with high-fat diet with or without GE. For same gene with different treatment groups, means in the different rows with different alphabets (a-d) were significantly different (p<0.05).

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