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Table 4 Effects of PF on transcript levels of proinflammatory cytokines TNF-α and IL-1β in different organs in DMN-induced rat liver fibrosis ( x ¯ ± s )

From: Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats

Group (number) Liver Spleen Lung Kidney
IL-1β (n-fold) TNF-α (n-fold) IL-1β (n-fold) TNF-α (n-fold) IL-1β (n-fold) TNF-α (n-fold) IL-1β (n-fold) TNF-α (n-fold)
Normal (3) 1.20±0.18 1.30±0.29 1.38±0.40 1.41±0.50 1.14±0.27 1.44±0.47 1.36±0.37 1.33±0.28
2-week DMN (3) 4.98±0.67 11.64±2.24 4.74±1.49 3.71±0.44 9.00±1.39 7.41±1.37 4.46±0.68 6.72±1.68
DMN-water (3) 3.89±0.72 6.09±1.86 3.80±1.36 3.38±0.47 11.09±3.34 11.24±2.13 1.99±0.53 2.24±0.57
DMN-PF (3) 2.97±0.39 4.50±0.74 2.82±0.30 2.28±0.34 4.09±0.97 3.13±0.28 1.76±0.19 1.70±0.19
DMN-GdCl3 (3) 3.52±0.84 3.49±0.75 3.37±1.16 2.68±0.46 9.73±1.85 10.07±2.53 1.69±0.30 1.55±0.45
  1. Δ p<0.05 versus 2-week DMN rats; p<0.05 versus DMN-water rats. Bonferroni’s multiple comparison test were used for group comparisons.