A. Comparison of wound depth and width in the four groups. Ovx = ovariectomized group; Ovx + EB = ovariectomized group receiving estradiol benzoate; Ovx + YCJ = ovariectomized group receiving young coconut juice. n = 6 in each group. ** P < 0.01 compared with the sham group. B-E. Sections from the dorsal skin wound areas following a 14-day-treatment period. (H&E; x4). The wound area is indicated by the yellow arrows. The wound area was the smallest in the Ovx+YCJ group (E), and the largest in the ovx group (C). Note the higher number and the bigger size of the hair follicles in the Ovx+YCJ group in both the dermis and hypodermis. B = Sham-operated group; C = Ovx group; D = Ovx+EB group; E = Ovx+YCJ group. e = epidermis; d = dermis; h = hypodermis. F-G. Epidermal thickness is indicated by the yellow arrows. The epidermis was the thinnest in the ovx group (F), and the thickest in the Ovx+YCJ group (G). Note that the collagen fibers (pink staining) in the dermis are much smaller and less in number in the ovx group, as compared to the Ovx+YCJ group. (H&E; x40).