Anti-ulcerogenic activity of the root bark extract of the African laburnum “Cassia sieberiana” and its effect on the anti-oxidant defence system in rats

Table 1 Effect of C. sieberiana (CS) root bark extract on ulcer index in ethanol-induced gastric ulcer rats

Treatment	Dose (mg/kg body wt.)	Mean Ulcer index [Score 0–10](Mean ± SEM)
Baseline (intact)	-	-
Ulcer control	Vehicle	8.00 ± 0.37
CS-extract	500	5.80 ± 0.31^a
“	750	4.00 ± 0.37^{b, c}
“	1000	1.17 ± 0.17^{b, d}
Ranitidine	50	1.50 ± 0.22^b

^a p< 0.05 compared with ulcer control; ^b p< 0.001 compared with ulcer control; ^c p< 0.05 compared with CS-500; ^d p< 0.01 compared with CS-750; Values are Mean ± SEM of 6 animals. Statistical significance was determined by one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc t test.

ISSN: 2662-7671