Safety and efficacy assessment of standardized herbal formula PM012

Sohn, Sung-Hwa; Kim, Soo-Jeong; Kim, Yong; Shim, Insop; Bae, Hyunsu

doi:10.1186/1472-6882-12-24

BMC Complementary Medicine and Therapies

Table 4 Serum biochemical values in rats orally treated with PM012

From: Safety and efficacy assessment of standardized herbal formula PM012

			Dose (mg/kg)
Parameter	Units	Sex	0			500		1000		2000
			4 Weeks	26 Weeks	Recovery	4 Weeks	26 Weeks	4 Weeks	26 Weeks	4 Weeks	26 Weeks	Recovery
AST	U/L	Male	113.90 ± 12.59	83.1 ± 11.4	90.0 ± 12.8	101.98 ± 14.09	78.5 ± 9.5	94.46 ± 12.02	85.9 ± 14.5	108.66 ± 24.97	84.1 ± 12.7	85.1 ± 21.5
		Female	97.10 ± 12.99	82.0 ± 10.0	83.9 ± 17.6	102.54 ± 16.78	81.9 ± 16.5	102.88 ± 7.01	81.9 ± 16.6	107.64 ± 21.81	80.3 ± 9.7	81.3 ± 13.2
ALT	U/L	Male	35.06 ± 4.56	50.3 ± 10.5	52.1 ± 10.3	34.10 ± 4.28	44.3 ± 6.6	35.56 ± 4.18	48.8 ± 12.9	34.68 ± 4.66	41.9 ± 6.7	52.6 ± 8.4
		Female	27.14 ± 3.54	37.3 ± 7.8	36.4 ± 3.6	25.96 ± 2.36	35.8 ± 3.7	27.64 ± 1.90	33.4 ± 5.6	27.06 ± 1.64	36.1 ± 6.5	35.2 ± 3.9
ALP	U/L	Male	133.96 ± 13.75	76.7 ± 11.9	84.6 ± 11.9	124.38 ± 9.96	77.0 ± 11.0	126.12 ± 9.52	79.5 ± 14.9	147.08 ± 19.36	73.1 ± 12.2	91.1 ± 9.1
		Female	87.20 ± 10.59	57.9 ± 12.2	54.1 ± 8.7	92.66 ± 15.55	62.3 ± 28.8	99.04 ± 18.32	50.6 ± 16.5	88.48 ± 3.48	54.7 ± 11.5	58.4 ± 13.4
CPK	U/L	Male	408.4 ± 68.2	101.6 ± 25.6	199.8 ± 118.8	291.6 ± 96.3	98.9 ± 20.5	212.4 ± 92.1	114.7 ± 49.5	261.0 ± 152.6	122.8 ± 65.9	135.2 ± 64.9
		Female	265.8 ± 110.2	104.1 ± 31.7	143.8 ± 70.5	266.6 ± 142.2	87.2 ± 45.2	227.8 ± 78.6	81.9 ± 28.9	282.0 ± 148.6	85.0 ± 33.1	161.2 ± 68.4
BIL	mg/dL	Male	0.21 ± 0.00	0.19 ± 0.02	0.19 ± 0.02	0.21 ± 0.00	0.21 ± 0.02	0.20 ± 0.01	0.19 ± 0.01	0.21 ± 0.01	0.20 ± 0.02	0.20 ± 0.01
		Female	0.21 ± 0.02	0.23 ± 0.03	0.26 ± 0.04	0.23 ± 0.02	0.23 ± 0.03	0.22 ± 0.02	0.23 ± 0.03	0.23 ± 0.02	0.24 ± 0.02	0.26 ± 0.05
GLU	mg/dL	Male	102.18 ± 9.12	116.8 ± 9.1	120.5 ± 9.5	99.94 ± 5.77	121.3 ± 12.3	108.70 ± 9.87	113.7 ± 11.4	109.38 ± 8.60	113.3 ± 9.8	121.0 ± 8.4
		Female	106.66 ± 7.29	107.6 ± 10.7	130.5 ± 14.1	99.86 ± 3.54	111.6 ± 15.7	100.10 ± 5.58	110.0 ± 11.2	99.30 ± 9.04	106.2 ± 12.2	132.0 ± 7.4
CHO	mg/dL	Male	90.4 ± 6.6	139.5 ± 27.3	165.0 ± 46.6	93.2 ± 12.8	152.9 ± 46.8	95.6 ± 9.4	123.2 ± 26.6	84.6 ± 9.9	116.0 ± 25.2	180.2 ± 73.0
		Female	96.8 ± 13.2	118.9 ± 13.0	119.0 ± 20.9	96.4 ± 20.6	119.1 ± 33.0	98.0 ± 11.6	138.5 ± 34.5	98.2 ± 17.2	126.4 ± 28.2	131.4 ± 24.5
TG	mg/dL	Male	45.2 ± 8.2	49.6 ± 8.3	54.8 ± 18.9	46.8 ± 11.1	61.1 ± 20.2	44.4 ± 7.1	46.0 ± 10.4	46.4 ± 7.4	47.7 ± 7.3	63.4 ± 34.0
		Female	36.0 ± 8.1	43.5 ± 5.5	39.6 ± 5.3	36.4 ± 7.7	43.2 ± 6.6	36.2 ± 4.1	48.1 ± 6.5	39.4 ± 6.5	47.6 ± 9.0	44.0 ± 13.1
PRO	g/dL	Male	6.04 ± 0.10	6.54 ± 0.14	6.38 ± 0.17	5.99 ± 0.23	6.48 ± 0.19	5.97 ± 0.10	6.42 ± 0.13	5.99 ± 0.24	6.50 ± 0.17	6.60 ± 0.21
		Female	5.63 ± 0.23	6.37 ± 0.16	6.84 ± 0.33	5.81 ± 0.38	6.65 ± 0.35	5.71 ± 0.23	6.60 ± 0.30	5.79 ± 0.13	6.76 ± 0.32	6.53 ± 0.20
ALB	g/dL	Male	3.17 ± 0.05	2.99 ± 0.10	2.85 ± 0.14	3.14 ± 0.08	2.95 ± 0.11	3.15 ± 0.04	2.97 ± 0.07	3.18 ± 0.11	3.07 ± 0.12	2.83 ± 0.21
		Female	3.05 ± 0.11	3.16 ± 0.10	3.44 ± 0.26	3.16 ± 0.12	3.34 ± 0.12	3.08 ± 0.09	3.27 ± 0.19	3.14 ± 0.04	3.38 ± 0.20	3.25 ± 0.16
A/G	ratio	Male	1.10 ± 0.00	0.84 ± 0.03	0.81 ± 0.09	1.10 ± 0.04	0.84 ± 0.08	1.12 ± 0.02	0.86 ± 0.05	1.14 ± 0.03	0.90 ± 0.06	0.76 ± 0.11
		Female	1.19 ± 0.05	0.98 ± 0.06	1.01 ± 0.10	1.20 ± 0.10	1.01 ± 0.05	1.17 ± 0.05	0.98 ± 0.05	1.18 ± 0.05	1.00 ± 0.05	0.99 ± 0.05
BUN	mg/dL	Male	16.94 ± 1.66	16.0 ± 2.7	17.1 ± 3.5	15.26 ± 1.69	16.4 ± 2.1	14.52 ± 1.38	15.8 ± 2.3	15.86 ± 1.88	14.7 ± 2.4	16.9 ± 2.9
		Female	16.48 ± 1.47	17.5 ± 1.2	15.2 ± 2.0	16.60 ± 1.02	17.3 ± 1.1	16.24 ± 1.39	17.7 ± 1.9	17.14 ± 0.66	16.9 ± 1.9	14.6 ± 1.5
CRE	mg/dL	Male	0.48 ± 0.07	0.57 ± 0.08	0.59 ± 0.07	0.49 ± 0.03	0.60 ± 0.04	0.48 ± 0.02	0.56 ± 0.03	0.50 ± 0.02	0.56 ± 0.02	0.62 ± 0.07
		Female	0.50 ± 0.03	0.63 ± 0.03	0.62 ± 0.04	0.52 ± 0.04	0.64 ± 0.05	0.53 ± 0.05	0.68 ± 0.07	0.53 ± 0.03	0.65 ± 0.05	0.61 ± 0.02
IP	mg/dL	Male	8.57 ± 0.35	5.96 ± 0.38	5.92 ± 0.53	8.59 ± 0.14	6.16 ± 0.36	8.43 ± 0.42	6.08 ± 0.44	8.76 ± 0.39	6.37 ± 0.59	6.13 ± 0.14
		Female	8.08 ± 0.62	5.69 ± 0.86	4.43 ± 0.28	7.96 ± 0.58	5.17 ± 1.28	8.08 ± 0.50	5.53 ± 0.71	7.95 ± 0.38	5.76 ± 0.79	4.68 ± 0.24
Ca²⁺	mg/dL	Male	10.53 ± 0.14	10.48 ± 0.15	10.30 ± 0.28	10.47 ± 0.21	10.41 ± 0.20	10.40 ± 0.18	10.26 ± 0.09	10.34 ± 0.25	10.32 ± 0.13	10.39 ± 0.05
		Female	10.08 ± 0.25	10.08 ± 0.21	10.48 ± 0.34	10.05 ± 0.22	10.19 ± 0.31	10.03 ± 0.32	10.13 ± 0.22	9.81 ± 0.18	10.20 ± 0.22	10.21 ± 0.28
Na⁺	mmol/L	Male	148.2 ± 0.8	145.3 ± 0.9	143.9 ± 1.2	148.2 ± 0.8	144.7 ± 1.0	148.2 ± 1.3	144.5 ± 0.8	148.6 ± 0.9	145.3 ± 1.3	143.2 ± 0.7
		Female	146.2 ± 1.3	145.0 ± 0.9	141.9 ± 1.1	145.2 ± 2.4	144.1 ± 1.2	143.8 ± 0.8	143.5 ± 1.3	144.0 ± 1.0	143.5 ± 0.9	142.0 ± 1.1
K⁺	mmol/L	Male	4.82 ± 0.13	4.32 ± 0.18	4.57 ± 0.23	4.71 ± 0.22	4.19 ± 0.17	4.75 ± 0.12	4.36 ± 0.20	4.72 ± 0.14	4.31 ± 0.21	4.37 ± 0.25
		Female	4.71 ± 0.16	3.99 ± 0.15	3.99 ± 0.24	4.52 ± 0.16	4.36 ± 1.08	4.53 ± 0.11	4.20 ± 1.08	4.53 ± 0.43	4.04 ± 0.29	3.96 ± 0.32
Cl^-	mmol/L	Male	108.8 ± 0.4	105.7 ± 0.7	104.5 ± 1.2	108.4 ± 1.1	105.0 ± 1.8	108.2 ± 0.8	106.1 ± 0.9	108.6 ± 0.5	105.2 ± 1.1	103.5 ± 1.0
		Female	109.2 ± 0.8	106.5 ± 1.4	104.6 ± 0.9	109.2 ± 0.8	107.1 ± 0.7	108.0 ± 1.2	106.4 ± 0.9	108.2 ± 0.8	105.9 ± 1.1	104.7 ± 1.5

*AST (Aspartate aminotransferase), ALT (Alanine aminotransferase), ALP (Alkaline phosphatase), CPK (Creatine phosphokinase), BIL (Total bilirubin), GLU (Glucose), CHO (Total cholesterol), TG (Triglyceride), PRO (Total protein), ALB (Albumin), A/G ratio (Albumin/Globulin ratio), BUN (Blood urea nitrogen), CRE (Creatinine), IP (Inorganic phosphorus), Ca²⁺ (Calcium ion), Na⁺ (Sodium ion), K⁺ (Potassium ion), Cl^- (Chloride ion).
Values are mean ± SD (n = 5 (4 weeks) or 10 (26 weks)/sex/dose). P < 0.05 compare with normal group.

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