Index | Body weight (g) | Water drinking (mL per rat) | feeding (g per rat) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
group | dose mg/kg | n | D0 | D14 | D21 | D28 | D0 | D14 | D21 | D28 | D0 | D14 | D21 | D28 |
Normal | — | 7 | 207 ± 12.0 | 328 ± 9.6 | 382 ± 12.1 | 389 ± 17.7 | 37.5 ± 0.0 | 56.9 ± 8.0 | 53.1 ± 2.7 | 51.3 ± 8.8 | 32.3 ± 11.1 | 31.1 ± 18.4 | 32.8 ± 2.4 | 33.8 ± 0.7 |
Sham | — | 7 | 214 ± 5.4 | 321 ± 18.9 | 384 ± 26.2 | 389 ± 28.3 | 54.4 ± 6.2 | 60.0 ± 14.1 | 60.6 ± 4.4 | 62.5 ± 7.1 | 38.4 ± 0.7 | 34.0 ± 3.0 | 32.0 ± 0.0 | 27.1 ± 5.1 |
Model | — | 7 | 213 ± 7.8 | 290 ± 16.2△△ | 332 ± 18.2△△ | 338 ± 26.0△△ | 41.3 ± 1.8 | 74.7 ± 1.9 | 54.0 ± 5.7 | 48.3 ± 11.8 | 8.7 ± 3.9△△ | 27.1 ± 1.6 | 27.7 ± 3.0 | 26.2 ± 1.9△△ |
Silymarin | 150 | 7 | 210 ± 6.2 | 260 ± 24.4 | 289 ± 15.8 | 291 ± 15.2 | 57.4 ± 1.9 | 85.0 ± 49.5 | 72.3 ± 0.9* | 59.3 ± 3.8* | 8.3 ± 2.7 | 26.9 ± 4.6 | 22.9 ± 0.4 | 21.0 ± 0.6 |
Berberine | 120 | 7 | 210 ± 6.2 | 294 ± 29.9 | 342 ± 31.0 | 340 ± 32.0 | 36.1 ± 0.2 | 76.3 ± 23.0 | 78.8 ± 3.1** | 62.5 ± 7.1** | 9.4 ± 1.0 | 25.7 ± 3.9 | 28.1 ± 1.9 | 28.9 ± 3.0 |
CRAE | 600 | 7 | 208 ± 6.0 | 275 ± 25.2 | 320 ± 3.5 | 324 ± 2.4 | 55.0 ± 14.1 | 70.8 ± 8.2 | 75.8 ± 5.9** | 61.3 ± 15.9* | 7.8 ± 1.7 | 21.6 ± 11.0 | 28.6 ± 3.9 | 28.7 ± 1.3 |
Bear bile | 200 | 7 | 207 ± 7.5 | 293 ± 38.5 | 331 ± 60.5 | 345 ± 64.7 | 34.4 ± 0.9 | 81.3 ± 1.8 | 75.6 ± 2.7** | 72.5 ± 10.6** | 8.2 ± 2.2 | 24.6 ± 1.2 | 28.2 ± 1.9 | 29.4 ± 0.8 |
TUDCA | 20 | 7 | 212 ± 5.5 | 279 ± 30.1 | 311 ± 58.9 | 307 ± 72.5 | 30.1 ± 5.5 | 76.7 ± 28.3 | 78.3 ± 11.8** | 63.3 ± 18.9* | 6.9 ± 2.6 | 24.2 ± 1.3 | 26.3 ± 2.1 | 24.8 ± 4.6 |