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Table 2 Selected genes more expressed (log2 ≥ 1.0) during S. cerevisiae exposure to propolis according to the GO term finder enrichment analysis (for a complete list of the genes more expressed, see Additional file 1: Table A1)

From: Transcriptional profiling of Saccharomyces cerevisiae exposed to propolis

Transmembrane Transport (GO:0055085) and Localization (GO:0051179) (p< 0.011)
FLR1 Multidrug transporter of the MFS, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs
PDR15 ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification
AZR1 Transporter of the MFS, involved in resistance to azole drugs such as ketoconazole and fluconazole
YOR1 ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
PDR10 ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network
PDR12 ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance
ENA1 P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
ENA2 P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux
VMA21 Membrane protein that is required for vacuolar H+−ATPase (V-ATPase) function, although not an actual component of the V-ATPase
TPO1 Polyamine transporter (MFS) that recognizes spermine, putrescine, and spermidine
TPO4 Polyamine transport protein (MFS) recognizes spermine, putrescine, and spermidine
ATG22 Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole
VMA7 Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+−ATPase (V-ATPase)
PKR1 V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase
Response to Stress (GO:0006950) and Response to Stimulus (GO:0050896) (p<0.009)
GRX4 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase
GTT3 Protein of unknown function with a possible role in glutathione metabolism
TSA2 Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen
GTT2 Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
GND2 6-phosphogluconate dehydrogenase, catalyzes an NADPH regenerating reaction in the pentose phosphate pathway
TRX1 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress