Table 6 Effect of Nuna kadugu on water consumption in experimental rats - repeated oral toxicity study
From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Treatment | Sex |  |  |      (ml) |  |  | ||
|---|---|---|---|---|---|---|---|---|
1stWeek | 2ndWeek | 3stWeek | 4stWeek | 5thWeek | 6thWeek | |||
Control (0.5% CMC) | M(n=5) | 100.80±12.45 | 101.00±15.37 | 100.40±6.96 | 100.80±11.34 |  |  | |
F (n=5) | 98.40±5.53 | 101. 00±11.05 | 101.80±12.68 | 101.40±13.95 | ||||
MF(n=10) | 99.60±6.43 | 101.00±8.92 | 101.10±6.82 | 101.10±8.48 | ||||
NK | (300 mg/kg p.o/day) | M(n=5) | 99.40±11.42 | 100. 20±9.61 | 101.20±16.83 | 100.60±13.67 | ||
F (n=5) | 101.60±5.71 | 101.40±11.28 | 100.60±9.09 | 101.60±11.51 | ||||
MF(n=10) | 100.50±6.03 | 100.80±6.99 | 100.90±9.02 | 101.10±8.42 | ||||
(600 mg/kg p.o/day) | M(n=5) | 98.80±11.89 | 101.80±9.05 | 101.00±19.24 | 100.80±14.37 | |||
F (n=5) | 100.00±7.29 | 100.80±8.00 | 102.20±17.30 | 100.40±11.21 | ||||
MF(n=10) | 99.40±6.58 | 101.30±5.70 | 101.60±12.20 | 100.60±8.59 | ||||
(900 mg/kg p.o/day) | M(n=5) | 99.80±9.61 | 100.40±5.35 | 100.20±9.44 | 98.80±7.00 | |||
F (n=5) | 100.20±12.48 | 99.80±6.97 | 99.60±6.10 | 101.20±16.49 | ||||
MF(n=10) | 100.00±7.43 | 100. 10±4.14 | 99.90±5.30 | 100.00±8.45 | ||||
Satellite group | ||||||||
Control (0.5% CMC) | M(n=5) | 101.60±8.35 | 102.60±7.12 | 100.80±15.63 | 102.40±13.55 | 101.40±10.62 | 100.40±19.44 | |
F (n=5) | 99.40±4.15 | 100.20±5.84 | 100.00±10.43 | 99.00±5.55 | 100.40±8.44 | 101.60±18.25 | ||
MF(n=10) | 100.50±4.41 | 101.40±4.36 | 100.40±8.86 | 100.70±6.93 | 100.90±6.40 | 101.00±12.57 | ||
NK (900 mg/kg p.o/day) | M(n=5) | 101.60±8.39 | 101.40±10.63 | 101.60±14.66 | 101.20±4.04 | 102.40±11.78 | 101.60±10.80 | |
F (n=5) | 99.40±13.01 | 99.80±8.26 | 100.60±11.29 | 101.60±11.71 | 101.00±14.32 | 102.20±12.29 | ||
MF(n=10) | 100.50±7.31 | 100.60±6.35 | 101.10±08.72 | 101.40±5.84 | 101.70±8.74 | 101.90±7.71 | ||