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Table 5 Effect of Nuna kadugu on feed intake in experimental rats - repeated oral toxicity study

From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats

Treatment Sex          (g)   
1stWeek 2ndWeek 3stWeek 4stWeek 5thWeek 6thWeek
Control (0.5% CMC) M(n=5) 80.60±3.61 82.20±7.44 89.40±7.86 101.00±1.64   
F (n=5) 83.40±6.08 90.00±5.42 87.00±6.94 90.20±11.06   
MF(n=10) 82.00±3.37 86.10±4.5 88.20±4.96 95.60±5.57   
NK (300 mg/kg p.o/day) M(n=5) 93.40±8.76 88.60±9.09 88.80±9.4 93.60±6.71   
F (n=5) 76.20±2.71 81.60±4.41 87.40±4.01 97.00±7.84   
MF(n=10) 84.80±5.19 85.10±4.90 88.10±4.86 95.30±4.90   
(600 mg/kg p.o/day) M(n=5) 87.40±5.64 93.00±4.60 92.80±4.12 96.60±5.27   
F (n=5) 73.40±4.98 78.60±4.32 85.80±4.6 92.80±3.81   
MF(n=10) 80.40±4.24 85.80±3.82 89.30±3.16 94.70±3.13   
(900 mg/kg p.o/day) M(n=5) 79.20±4.07 76.00±3.7 79.80±4.19 97.60±2.36   
F (n=5) 85.80±11.83 92.80±8.76 102.00±5.30 90.60±11.38   
MF(n=10) 82.50±6.00 84.40±5.30 90.90±4.88 94.10±5.60   
Satellite group
Control (0.5% CMC) M(n=5) 81.80±7.79 86.20±9.47 85.80±9.97 80.80±8.80 100.60±8.49 99.40±14.08
F (n=5) 82.00±7.13 89.40±5.87 92.20±1.46 109.80±1.02 98.00±10.21 99.20±7.62
MF(n=10) 81.90±4.98 87.80±5.28 89.00±4.87 95.306.39± 99.30±6.28 99.30±7.55
NK (900 mg/kg p.o/day) M(n=5) 82.40±6.93 89.00±7.50 82.00±5.02 103.60±4.74 98.00±8.63 99.20±6.88
F (n=5) 81.40±5.99 81.20±3.71 93.80±4.76 91.00±9.73 100.40±3.88 99.80±9.44
MF(n=10) 81.90±4.32 85.10±4.15 87.90±5.02 97.30±5.52 99.20±4.48 99.50±5.51
  1. Values expressed as mean ± SEM; g – gram; Significance with Tukey’s test following one way ANOVA is evaluated as * p < 0.05 and ** p < 0.01 vs control group.