Table 10 Effect of Nuna kadugu on organ weight of experimental Sprague Dawley rats in repeated oral toxicity study
From: Acute toxicity and the 28-day repeated dose study of a Siddha medicine Nuna Kadugu in rats
Treatment | Sex | Organ Weight (gms) | |||||
|---|---|---|---|---|---|---|---|
Kidneys | Adrenals | Thymus | Testis/Ovaries | Epididymis | |||
Control (0.5% CMC) | M(n=5) | 1.65±0.13 | 0.05±0.01 | 0.48±0.01 | 2.06±0.42 | 1.43±0.03 | |
F (n=5) | 1.34±0.13 | 0.04±0.00 | 0.48±0.03 | 0.08±0.02 | - | ||
MF(n=10) | 1.49±0.10 | 0.04± 0.00 | 0.48±0.01 | - | - | ||
NK | (300 mg/kg p.o/day) | M(n=5) | 1.79±0.12 | 0.05±0.01 | 0.48±0.01 | 2.09±0.17 | 1.41±0.03 |
F (n=5) | 1.35±0.04 | 0.05±0.01 | 0.49±0.02 | 0.32±0.02 | - | ||
MF(n=10) | 1.57±0.09 | 0.05±0.00 | 0.48±0.01 | - | - | ||
(600 mg/kg p.o/day) | M(n=5) | 1.61±0.10 | 0.04±0.00 | 0.47±0.02 | 1.96±0.19 | 1.47±0.03 | |
F (n=5) | 1.36±0.07 | 0.04±0.00 | 0.48±0.01 | 0.08±0.01 | - | ||
MF(n=10) | 1.49±0.07 | 0.04±0.00 | 0.47±0.01 | - | - | ||
(900mg/kg p.o/day) | M(n=5) | 1.64±0.14 | 0.04±0.00 | 0.47±0.01 | 2.22±0.38 | 1.49±0.03 | |
F (n=5) | 1.37±0.08 | 0.05±0.01 | 0.52±0.03 | 0.09±0.01 | - | ||
MF(n=10) | 1.51±0.09 | 0.05±0.00 | 0.49±0.02 | - | - | ||
Satellite group | |||||||
Control (0.5% CMC) | M(n=5) | 1.51±0.12 | 0.05±0.01 | 0.46±0.02 | 1.98±0.43 | 1.41±0.03 | |
F (n=5) | 1.34±0.07 | 0.05±0.00 | 0.49±0.02 | 0.10±0.01 | - | ||
MF(n=10) | 1.42±0.07 | 0.05±0.00 | 0.48±0.01 | - | - | ||
NK (900 mg/kg p.o/day) | M(n=5) | 1.68±0.10 | 0.05±0.00 | 0.490.02 | 2.04±0.31 | 1.54±0.02 | |
F (n=5) | 1.35±0.05 | 0.05±0.00 | 0.51±0.03 | 0.12±0.00 |  | ||
MF(n=10) | 1.51±0.08 | 0.05±0.00 | 0.50±0.02 | 1.98±0.43 |  | ||