Figure 5

Effects of CTS administration on EPM performance of db/db mice. The animals received an EPM test at around the age of 13 weeks old. The 7-week-old db/db mice were orally administered water (vehicle), 375 – 750 mg/kg CTS, 2.5 mg/kg THA once daily during the experimental period. The EMT was conducted 1 hr after CTS administration. The age-matched naïve db/db mice received i.p. injection of 1 mg/kg diazepam 30 min before the test. Each datum represents the mean ± S.D. (6 – 9 animals per group). The proportion of time spent in open arms (A) and the total locomotion distance on the maze (B) were calculated. The data are expressed as the mean ± S.D. ###P < 0.001 vs. vehicle-treated m/m group (Student’s t-test). *P < 0.05, **P < 0.01 vs. vehicle-treated db/db group (one-way ANOVA followed by Tukey test).