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Table 3 Effect of Rutin on Genotoxicity studies

From: CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat

Treatment

AgNORS (NORs/cell)

%DNA fragmentation

% oxo8dG

% p53

% CYP 2E1

Control

2.02±0.33++

5.33±1.46++

4.10±0.53++

7.13±0.63++

15.23±1.09++

3 ml/kg CCl4

6.42±0.29**

22.50±3.68**

11.20±0.27**

3.41±0.49**

8.10±0.78**

50 mg/kg Rutin+CCl4

3.32±0.76++

7.61±1.04++

6.13±0.26++

5.15±0.46++

12.16±1.04++

70 mg/kg Rutin+CCl4

3.11±0.35++

5.00±1.83++

5.20±0.85++

7.10±0.55++

14.22±1.33++

  1. Mean ±SE (n=6 number).
  2. ** indicate significance from the control group at P< 0.01 probability level.
  3. ++ indicate significance from the CCl4 group at P< 0.01 probability level.