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Table 3 Effect of Rutin on Genotoxicity studies

From: CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat

Treatment AgNORS (NORs/cell) %DNA fragmentation % oxo8dG % p53 % CYP 2E1
Control 2.02±0.33++ 5.33±1.46++ 4.10±0.53++ 7.13±0.63++ 15.23±1.09++
3 ml/kg CCl4 6.42±0.29** 22.50±3.68** 11.20±0.27** 3.41±0.49** 8.10±0.78**
50 mg/kg Rutin+CCl4 3.32±0.76++ 7.61±1.04++ 6.13±0.26++ 5.15±0.46++ 12.16±1.04++
70 mg/kg Rutin+CCl4 3.11±0.35++ 5.00±1.83++ 5.20±0.85++ 7.10±0.55++ 14.22±1.33++
  1. Mean ±SE (n=6 number).
  2. ** indicate significance from the control group at P< 0.01 probability level.
  3. ++ indicate significance from the CCl4 group at P< 0.01 probability level.