Table 2 QoL-Questionnaires: difference between treatment group (aVQ) and control group by independent t -test and result of the repeated measured analysis of variance (ANOVA, influence of treatment)
Values at baseline (SD) | Difference between aVQ and control | |||||||
|---|---|---|---|---|---|---|---|---|
aVQ | Control | t | t | t | t | F | ||
baseline | week 8 | week 16 | week 24 | ANOVA | ||||
Global health status | 43.75 (12.73) | 38.33 (22.45) | −0.8192 | −0.7853 | −4.3243** | −2.2335* | 7.7133** | |
Function scales QLQ-C30 | Physical Function | 60.83 (18.52) | 59.11 (18.66) | −0.2577 | 0.7034 | −1.1736 | −0.4788 | 0.2499 |
Role Function | 61.46 (35.34) | 54.44 (30.52) | −0.5925 | 0.9454 | −1.616 | −0.5529 | 0.4646 | |
Emotional Function | 60.94 (21.02) | 55.56 (28.64) | −0.5933 | 0.2221 | 2.2619* | 0.0475 | 0.0851 | |
Cognitive Function | 75.00 (21.94) | 77.78 (15.00) | 0.4137 | 1.209 | 1.5594 | −0.2262 | 1.0832 | |
Social Function | 58.33 (29.81) | 58.89 (35.56) | 0.047 | −0.684 | 0.7015 | −0.396 | 0.0107 | |
Symptom scales QLQ-C30 | Fatigue | 44.44 (17.68) | 48.89 (27.47) | 0.5317 | −0.1426 | −0.4653 | 0.3975 | 0.0812 |
Nausea &Vomiting | 17.71 (18.73) | 5.56 (13.61) | −2.0761 | −0.764 | −1.1565 | 0.102 | 2.6182 | |
Pain | 51.04 (21.49) | 55.56 (33.73) | 0.4411 | −0.9279 | −0.2941 | 0.6467 | 0.0258 | |
Dyspnoea | 25.00 (28.54) | 33.33 (35.63) | 0.7157 | 0.4233 | −1.1535 | −0.5658 | 0.0023 | |
Insomnia | 37.50 (29.50) | 53.33 (37.37) | 1.3036 | −1.2579 | 0.130 | −0.8726 | 0.0214 | |
Appetite loss | 33.33 (27.22) | 37.78 (35.34) | 0.3905 | 0.6096 | −0.2297 | 0.7067 | 0.4156 | |
Constipation | 31.11 (34.43) | 22.22 (27.22) | −0.7845 | −0.1521 | −0.5357 | −0.7574 | 0.7652 | |
Diarrhea | 22.22 (24.12) | 15.56 (24.77) | −0.7467 | −0.6185 | −2.6407* | −1.0367 | 3.606 | |
Financial difficulties | 37.50 (34.16) | 28.89 (27.79) | −0.772 | −0.0922 | −1.6535 | −0.8739 | 1.0459 | |
Symptoms QLQ-STO22 | Dysphagia | 34.03 (22.76) | 46.67 (21.50) | 1.5901 | −0.1442 | 1.0202 | 0.4126 | 1.7228 |
Pain | 43.75 (26.44) | 63.89 (25.13) | 2.1742* | 0.757 | −0.7438 | 0.3681 | 1.9013 | |
Reflux symptom | 27.08 (15.70) | 22.22 (23.76) | −0.6676 | −1.2596 | −1.7927 | −1.0456 | 3.1538 | |
Eating restriction | 29.17 (22.57) | 46.11 (20.62) | 2.1843* | 0.2106 | 0.7307 | 0.1629 | 2.3484 | |
Anxiety | 42.36 (23.38) | 40.00 (28.73) | −0.25 | −1.5867 | −0.0319 | 0.4544 | 0.2471 | |
Single items QLQ-STO22 | Having a dry mouth | 39.58 (30.35) | 57.78 (36.66) | 1.4998 | −1.0582 | −1.1941 | −1.3797 | 0.1782 |
Taste | 22.92 (23.47) | 40.00 (31.37) | 1.708 | −0.4383 | 0.7737 | 0.6099 | 1.4529 | |
Body image | 41.67 (28.54) | 33.33 (30.86) | −0.7791 | −2.3885* | −0.0962 | 0.00 | 1.4123 | |
Hair loss | 20.00 (18.26) | 83.33 (33.33) | 3.4125* | 0.5143 | 0.4672 | −1.4018 | 1.4885 | |