Effect on protein oxidation. Inhibitory effect of TCME on protein oxidation levels in iron overloaded mice. Mice were randomly divided into six groups (blank, B; control, C; 50 mg/kg b.w. TCME, S50; 100 mg/kg b.w. TCME, S100; 200 mg/kg b.w. TCME, S200; desirox group, D) and treated as described in ‘experimental design’ section. Protein carbonyl content was assayed to measure the extent of protein oxidation. Values are expressed as mean ± SD (n = 6). ***p ≤ 0.001 compared with blank and #
p ≤ 0.05, ###
p ≤ 0.001 compared with control.