Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso

Konaté, Kiessoun; Bassolé, Imaël Henri Nestor; Hilou, Adama; Aworet-Samseny, Raïssa RR; Souza, Alain; Barro, Nicolas; Dicko, Mamoudou H; Datté, Jacques Y; M’Batchi, Bertrand

doi:10.1186/1472-6882-12-120

BMC Complementary Medicine and Therapies

Table 1 Effect of Aqueous Acetone Extracts of Sida acuta and Sida cordifolia on the haematological parameters on whole blood of rats

From: Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso

Haematological parameters	Group 1	Group 2	Group 3	Group 4
Sida acuta Aqueous Acetone Extract
WBC(10³/μl)	12.43 ± 3.20	12.19 ± 0.10^ns	11.69 ± 1.20^ns	11.77 ± 0.11^ns
RBC (10⁶/μl)	7.17 ± 1.18	7.23 ± 2.36^ns	7.13 ± 1.03^ns	7.08 ± 0.88^ns
Eosinophil (%)	2.18 ± 0.68	2.21 ± 1.08^ns	2.00 ± 2.20^ns	2.11 ± 4.53^ns
Lymphocyte (%)	78.11 ± 0.24	77.85 ± 1.57^ns	77.69 ± 1.43^ns	78.00 ± 2.21^ns
Neutrophil (%)	25.89 ± 0.09	25.78 ± 0.31^ns	25.59 ± 1.43^ns	25.81 ± 1.21^ns
Monocyte (%)	1.57 ± 0.24	1.02 ± 1.20*	1.00 ± 1.43*	0.91 ± 1.21*
Basophil (%)	0.17 ± 0.09	0.13 ± 0.31^ns	0.11 ± 0.43**	0.12 ± 0.22^ns
Haemoglobin (g/dl)	15.23 ± 1.13	14.69 ± 0.15^ns	14.21 ± 0.63*	14.11 ± 0.77 *
Haematocrit (%)	43.46 ± 2.20	44.00 ± 1.21^ns	42.43 ± 3.20*	40.61 ± 1.2**
MCV (μm³)	57.00 ± 0.48	56.48 ± 1.28^ns	55.35 ± 0.15*	54.79 ± 2.30**
MCH (pg)	18.87 ± 1.20	18.62 ± 0.43^ns	18.90 ± 1.22^ns	18.49 ± 0.67^ns
MCHC (g/dl)	33.78 ± 0.11	33.35 ± 2.22^ns	33.00 ± 0.40^ns	33.13 ± 1.22^ns
Platelet (x10³/μl)	967.42 ± 4.12	961.11 ± 5.10 ^ns	953.22 ± 2.35 ^ns	964.00 ± 1.10 ^ns
Sida cordifolia Aqueous Acetone Extract
WBC(10³/μl)	12.21 ± 2.21	12.08 ± 0.54^ns	12.00 ± 1.10^ns	12.02 ± 1.22^ns
RBC (10⁶/μl)	7.29 ± 0.21	7.45 ± 0.15^ns	7.22 ± 0.59^ns	7.10 ± 0.27^ns
Eosinophil (%)	2.23 ± 1.03	2.14 ± 0.56^ns	2.00 ± 0.53^ns	2.17 ± 4.53^ns
Lymphocyte (%)	78. 31 ± 1.03	77.60 ± 0.88^ns	77.62 ± 1.20^ns	76.89 ± 0.22*
Neutrophil (%)	26.13 ± 0.68	26.00 ± 1.08^ns	25.78 ± 2.15^ns	26.13 ± 2.33^ns
Monocyte (%)	2.01 ± 0.09	0.76 ± 0.31*	0.82 ± 1.43*	0.91 ± 1.21*
Basophil (%)	0.2 ± 0.24	0.17 ± 0.10^ns	0.17 ± 1.25^ns	0.13 ± 0.36*
Haemoglobin (g/dl)	15.02 ± 1.43	14.40 ± 0.31^ns	14.23 ± 0.54^ns	14.75 ± 1.21^ns
Haematocrit (%)	42.83 ± 2.21	42.60 ± 1.10^ns	41.67 ± 0.33*	42.00 ± 0.22^ns
MCV (μm³)	56.78 ± 0.15	56.62 ± 0.34^ns	56.41 ± 2.10^ns	56.80 ± 0.33^ns
MCH (pg)	19.61 ± 0.24	19.57 ± 0.22^ns	19.07 ± 1.20^ns	19.55 ± 0.36^ns
MCHC (g/dl)	33.26 ± 0.1	33.51 ± 0.54^ns	33.37 ± 2.21^ns	33.00 ± 0.2^ns
Platelet (x10³/μl)	960.11 ± 0.33	957.23 ± 0.67^ns	963.47 ± 1.63^ns	966.40 ± 0.67^ns

WBC: leucocyte count; RBC: erythrocyte count; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration.
Values are mean ± S.E.M. (n = 6) one-way ANOVA followed by Dunnett’s t- test: Compare all vs. control: p>0.05, *p <0.05, **p <0.01 compared with control
Group 1: control, rats received 10% DMSO.
Group 2: rats received 10% DMSO with extract (75 mg/kg body weight).
Group 3: rats received 10% DMSO with extract (100 mg/kg body weight).
Group 4: rats received 10% DMSO with extract (200 mg/kg body weight).

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