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Table 3 Biochemical parameters of nondiabetic mice, untreated diabetic mice and diabetic mice treated with WSDP or EEP

From: Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice

  Nondiabetic micea Diabetic miceb Diabetic mice + (0.5% EtOH) Diabetic mice + EEPc Diabetic mice + WSDPc
ALP (U L-1) 53.75 ± 7.50 83.33 ± 16.07# 95 ± 10.80## 71.25 ± 20.15 65 ± 10.80
AST (U L-1) 146.25 ± 13.50 186.25 ± 31.72 183.75 ± 41.70 167.5 ± 29.58 161.25 ± 29.54
ALT (U L-1) 57.5 ± 9.36 81.25 ± 9.46 90 ± 15.35 66.25 ± 11.09* 60 ± 10.80*
LD (g L-1) 1881 ± 298.48 2246.25 ± 157.92# 2487.5 ± 253.42# 995 ± 358.86*** ΔΔΔ 586.25 ± 90.68**ΔΔ
TP (g L-1) 48.5 ± 4.38 44.5 ± 1.96 48.75 ± 4.92 40.75 ± 4.78 40.875 ± 1.93 Δ
GLU (mmol L-1) 9.89 ± 0.64 30.52 ± 5.34## 25.575 ± 4.55# 32.57 ± 7.47 ΔΔΔ 47.75 ± 6.35 ΔΔ
UREA (mmol L-1) 7.5 ± 1.22 9.125 ± 0.42 9.88 ± 1.89 13.625 ± 3.45 Δ 7.88 ± 2.43
Cholesterol (mmol L-1) 3.52 ± 0.26 3.20 ± 1.00 3.20 ± 0.80 4.14 ± 2.36 3.55 ± 0.72
Triglycerides (mmol L-1) 2.72 ± 0.16 3.00 ± 0.90 3.37 ± 1.11 2.20 ± 0.97 2.56 ± 0.92
  1. aControl group of nondiabetic mice received 0.5 mL physiological solution intraperitonealy (ip) for 7 consecutive days starting starting 2 days after aloxan injection.
  2. bDiabetic mice; injected iv with alloxan in a single dose of 75 mg kg-1 body weight and served as untreated diabetic group.Untreated diabetic mice received 0.5 mL physiological solution or 0.5% ethanolic solution intraperitonealy (ip) for 7 consecutive days starting starting 2 days after aloxan injection.
  3. cDiabetic mice treated with WSDP or EEP ip in a daily dose of 50 mg kg-1 for 7 days starting 2 days after alloxan injection.
  4. *Statistically significant difference between WSDP or EEP treated diabetic mice and untreated diabetic animals (*P <0.05; P** < 0.01; Student t-test).
  5. # Statistically significant difference between untreated diabetic mice and nondiabetic animals (## P <0.01; Student t-test).
  6. Δ Statistically significant difference between nondiabetic animals and WSDP or EEP treated diabetic mice (Δ P <0.05; ΔΔ P <0.01; ΔΔΔ P <0.001; Student t-test).