Figure 2

Liver of diabetic mice stained with HE. (A-B) Diabetic mice treated with physiological solution. (A) Hepatocytes around Kiernan’s spaces (Ks) are more vacuolized then cells around central vein (vc). (B) Focal hemorrhagic necrosis. (C) Diabetic mice treated with WSDP show less vacuolized hepatocytes. Dilatated sinusoids and swollen hepatocytes without vacuoles can be seen around central vein (vc). Cells around Kiernan’s space (Ks) are not swollen, some are weakly vacuolized. (D-E) Diabetic mice treated with ethanolic solution (0.5% EtOH). (D) Hepatocytes around central vein (vc) are more intensively vacuolized then cells around Kiernan’s space (Ks). (E) Increased number and level of vacuolized hepatocytes in whole lobule. (F) Diabetic mice treated with EEP. Hepatocytes are less vacuolized compared to diabetic mice. Bar = 20 μm.