The subcutaneous tumors in NCR nude mice (a): Untreated group (1), and the treated group at 0.5% wt/wt of the xanthones extract (2). Analysis of tumor size (b): analysis of tumor size versus time (days) after treatment with the xanthones extract at 2 doses 0.5% and 0.25% wt/wt compared to the control group (untreated). (*) refers to significant difference between both treated groups (P < 0.05) and the control, and (#) refers to significant difference between the 0.5% group and the control in each corresponding interval. Cross sections of tumor tissues (c): untreated animals (1), 0.5% treated group (2) and the 0.25% treated group (3). The tissues were stained with Hematoxylin-eosin and the pictures were captured at 5× magnification. (N) refers to necrotic cells and (V) refers to viable tumor cells.