|
Characteristic
|
MSM (N = 25)
|
Placebo (N = 25)
|
p value*
|
|---|
|
Kellgren and Lawrence Grade
|
|
Grade 1
|
4
|
8
| |
|
Grade 2
|
7
|
6
| |
|
Grade 3
|
4
|
6
| |
|
Grade 4
|
10
|
5
|
0.324
|
|
Male gender
|
4
|
13
|
0.007*
|
|
Age
|
67.0 ± 9.8
|
71.0 ± 8.3
|
0.203
|
|
Body mass index (BMI)
|
31.4 ± 5.4
|
28.6 ± 3.09
|
0.037*
|
|
WOMAC (0-100 mm scale)
|
|
Pain subscale
|
42.4 ± 25.7
|
45.9 ± 27.4
|
0.641
|
|
Stiffness subscale
|
46.7 ± 24.8
|
43.0 ± 35.6
|
0.671
|
|
Function subscale
|
39.9 ± 21.2
|
47.4 ± 21.9
|
0.221
|
|
Aggregated total score
|
40.9 ± 20.3
|
47.0 ± 22.2
|
0.100
|
|
ALF (seconds)
|
|
8 meter walk time
|
9.4 ± 3.9
|
8.2 ± 2.1
|
0.172
|
|
Stand-sit-stand transfer time
|
10.4 ± 5.3
|
8.4 ± 2.4
|
0.106
|
|
Stair ascent and descent time
|
23.9 ± 15.1
|
16.5 ± 5.8
|
0.029*
|
|
ALF score
|
43.6 ± 23.2
|
33.1 ± 9.6
|
0.043*
|
|
SF-36 (0-100 scale)
|
|
SF-36 score results
|
54.1 ± 18.9
|
58.0 ± 17.2
|
0.446
|
|
Visual-analogue-scale for pain
|
3.78 ± 3.04
|
4.60 ± 2.74
|
0.320
|
|
Knee Society Knee Score
|
60.04 ± 15.6
|
59.5 ± 17.1
|
0.911
|
|
Knee Society Function Score
|
60.4 ± 17.2
|
58.9 ± 13.1
|
0.734
|
- Values are presented as mean ± SD.
- * The significance threshold was set at p ≤ 0.05.
- MSM = methylsulfonylmethane; WOMAC = Western Ontario and McMaster Osteoarthritis Index; ALF = aggregated locomotor function; SF-36 = 36-item short-form health survey.
- There were significant differences between the groups at baseline in gender, BMI and ALF score. Results of the study were adjusted to account for these differences.
