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Table 2 Antiplasmodial (APM) activity and selectivity index (SI) of leaf extracts of Apocynaceae species

From: Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species

Species cLeaf extract aEC50(μg/ml) of APM activity bIC50(μg/ml) of APF activity bSI of APM activity
   K1 3D7 HepG2 MCF-7 HepG2 MCF-7
Alstonia angustiloba HEX 7.81 -     
  DCM - -     
  DCM:MeOH 0.46 - >25.0 >25.0 NC NC
  MeOH 6.46 -     
Calotropis gigantea HEX 5.82 -     
  DCM - -     
  DCM:MeOH 0.97 3.29 >25.0 16.8 NC 17.3
  MeOH - -     
Dyera costulata HEX - -     
  DCM - 8.31     
  DCM:MeOH 7.52 2.13     
  MeOH 7.74 3.56     
Kopsia fruticosa HEX - -     
  DCM - 7.14     
  DCM:MeOH 4.35 -     
  MeOH 1.01 -     
Vallaris glabra HEX 1.00 - >25.0 >25.0 NC NC
  DCM 0.85 - >25.0 12.0 NC 14.1
  DCM:MeOH 8.45 -     
  MeOH 8.42 -     
d Standard drug       
Artemisinin 0.001 0.001     
Mefloquine 0.008 0.018     
  1. a EC50 or effective concentration (μg/ml) is the extract concentration that kills 50% of malaria parasites. Activity is not effective (-) if EC50 value >10 μg/ml. K1 and 3D7 are chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, respectively.
  2. b IC50 of antiproliferative (APF) activity and SI of APM activity against HepG2 and MCF-7 cells were calculated only for the most potent extracts against K1 strain with EC50 ≤1.00 μg/ml. NC, non-cytotoxic with SI values >25.0.
  3. c HEX, hexane; MeOH, methanol; DCM, dichloromethane.
  4. d Standard drugs of artemisinin and mefloquine are used as positive controls.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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