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Table 1 Antiproliferative activity of leaf extracts of three Apocynaceae species against six human cancer cell linesa

From: Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species

Species cLeaf extract bGI50(μg/ml)
   MCF-7 MDA-MB-231 HeLa HT-29 SKOV-3 HepG2
Alstonia angustiloba HEX - - - - - -
  DCM - 20 ± 1.7 20 ± 1.1 - 16 ± 1.4 -
  DCM:MeOH - - - - - -
  MeOH - - - - - -
Calotropis gigantea HEX - - - - - -
  DCM 1.9 ± 0.2 1.3 ± 0.3 2.5 ± 0.5 3.3 ± 0.2 2.5 ± 0.2 1.8 ± 1.7
  DCM:MeOH 13 ± 0.3 - 15 ± 1.0 24 ± 0.7 20 ± 2.3 16 ± 3.5
  MeOH - - - - - -
Vallaris glabra HEX - - - - - -
  DCM 7.7 ± 1.3 12 ± 2.0 9.8 ± 1.5 9.3 ± 2.0 7.5 ± 4.5 7.6 ± 0.2
  DCM:MeOH 7.0 ± 2.5 13 ± 6.3 8.5 ± 2.9 12 ± 1.2 7.7 ± 2.4 5.8 ± 1.2
  MeOH 16 ± 2.1 - - - - 19 ± 0.9
d Standard drug       
Xanthorrhizol 11 ± 0.7 8.7 ± 0.8     
Curcumin 4.1 ± 0.9 8.7 ± 0.8     
Tamoxifen 8.3 ± 0.6 4.6 ± 0.5     
  1. a Initial screening showed that extracts of Dyera costulata and Kopsia fruticosa did not show any APF activity.
  2. b GI50 (μg/ml) is growth inhibition (GI) of cancer cell lines by 50%. Inhibition is not effective (-) with values >20 μg/ml. MCF-7 and MDA-MB-231, HeLa and SKOV-3, HT-29, and HepG2 are human breast, cervical, colon and liver cancer cell lines, respectively.
  3. c HEX, hexane; DCM, dichloromethane; MeOH, methanol.
  4. d Data on standard drugs of xanthorrhizol, curcumin and tamoxifen against MCF-7 and MDA-MD-231 cell lines are from an earlier publication [24].