Skip to main content

Table 1 Antiproliferative activity of leaf extracts of three Apocynaceae species against six human cancer cell linesa

From: Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species

Species

cLeaf extract

bGI50(μg/ml)

  

MCF-7

MDA-MB-231

HeLa

HT-29

SKOV-3

HepG2

Alstonia angustiloba

HEX

-

-

-

-

-

-

 

DCM

-

20 ± 1.7

20 ± 1.1

-

16 ± 1.4

-

 

DCM:MeOH

-

-

-

-

-

-

 

MeOH

-

-

-

-

-

-

Calotropis gigantea

HEX

-

-

-

-

-

-

 

DCM

1.9 ± 0.2

1.3 ± 0.3

2.5 ± 0.5

3.3 ± 0.2

2.5 ± 0.2

1.8 ± 1.7

 

DCM:MeOH

13 ± 0.3

-

15 ± 1.0

24 ± 0.7

20 ± 2.3

16 ± 3.5

 

MeOH

-

-

-

-

-

-

Vallaris glabra

HEX

-

-

-

-

-

-

 

DCM

7.7 ± 1.3

12 ± 2.0

9.8 ± 1.5

9.3 ± 2.0

7.5 ± 4.5

7.6 ± 0.2

 

DCM:MeOH

7.0 ± 2.5

13 ± 6.3

8.5 ± 2.9

12 ± 1.2

7.7 ± 2.4

5.8 ± 1.2

 

MeOH

16 ± 2.1

-

-

-

-

19 ± 0.9

d Standard drug

      

Xanthorrhizol

11 ± 0.7

8.7 ± 0.8

    

Curcumin

4.1 ± 0.9

8.7 ± 0.8

    

Tamoxifen

8.3 ± 0.6

4.6 ± 0.5

    
  1. a Initial screening showed that extracts of Dyera costulata and Kopsia fruticosa did not show any APF activity.
  2. b GI50 (μg/ml) is growth inhibition (GI) of cancer cell lines by 50%. Inhibition is not effective (-) with values >20 μg/ml. MCF-7 and MDA-MB-231, HeLa and SKOV-3, HT-29, and HepG2 are human breast, cervical, colon and liver cancer cell lines, respectively.
  3. c HEX, hexane; DCM, dichloromethane; MeOH, methanol.
  4. d Data on standard drugs of xanthorrhizol, curcumin and tamoxifen against MCF-7 and MDA-MD-231 cell lines are from an earlier publication [24].
Back to article page

BMC Complementary Medicine and Therapies

ISSN: 2662-7671

Contact us