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Table 2 Pharmacokinetic parameters of 5-FU (48 mg/kg) after a single i.p. injection to control rats (n = 5) or rats pretreated with TC extract (n = 5).

From: Anticancer activity of an extract from needles and twigs of Taxus cuspidata and its synergistic effect as a cocktail with 5-fluorouracil

Parameter

Control group

Extract-pretreated group

AUC(μg/ml) × min

2317.81 ± 370.12

2864.17 ± 757.25

Tmax(min)

12.53 ± 4.88

16.23 ± 3.79

Cmax(μg/ml)

24.84 ± 7.45

23.32 ± 4.95

V/F(mg/kg)/(μg/ml)

1.77 ± 0.63

1.83 ± 0.41

T1/2(ke)(min)

58.5 ± 19.67

72.6 ± 8.93

T1/2(ka)(min)

3.05 ± 1.82

3.62 ± 1.14

  1. AUC: area under the curve; Tmax: time to reach the maximum concentration; Cmax: maximum concentration; V/F: apparent volume of distribution; T1/2(ke): elimination half-life; T1/2(ka): absorption half-life. Values are means ± SD of 5 animals. There was no significant difference between the two groups.