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Table 6 Laboratory parameters (means ± standard deviation) in the ITT population.

From: Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjects

  Group Baseline Exposure Exposure Exposure Follow-up
    Week 4 Week 8 Week 12 Week 16
Hemoglobin (mg/dl) IP 14.0 ± 1.0 14.0 ± 0.9 13.9 ± 1.0 14.0 ± 0.9 14.0 ± 0.9
  VM 13.6 ± 1.1 13.7 ± 1.0 13.7 ± 1.0 13.5 ± 1.1 13.6 ± 1.1
  PL 13.8 ± 0.9 13.8 ± 1.0 14.0 ± 1.1 13.8 ± 1.1 13.8 ± 1.1
Hematocrit (%) IP 41.6 ± 2.6 41.7 ± 2.4 41.2 ± 2.6 41.4 ± 2.5 41.4 ± 2.1
  VM 40.7 ± 2.8 41.1 ± 2.7 40.7 ± 2.9 40.4 ± 3.1 40.5 ± 2.8
  PL 41.4 ± 2.1 41.4 ± 2.5 41.8 ± 2.7 41.3 ± 2.7 41.4 ± 2.8
Platelets (1000/μl) IP 272 ± 52 259 ± 43 271 ± 44 256 ± 41* 250 ± 44
  VM 269 ± 46 272 ± 62 260 ± 59 251 ± 55* 256 ± 65
  PL 267 ± 56 265 ± 52 274 ± 66 271 ± 56 254 ± 52
Calcium (mmol/l) IP 2.4 ± 0.0 2.4 ± 0.1 2.4 ± 0.0 2.4 ± 0.0 2.4 ± 0.0
  VM 2.3 ± 0.0 2.4 ± 0.1 2.4 ± 0.0 2.4 ± 0.0 2.4 ± 0.1
  PL 2.4 ± 0.0 2.4 ± 0.0 2.4 ± 0.0 2.4 ± 0.0 2.4 ± 0.1
Potassium (mmol/l) IP 4.3 ± 0.2 4.3 ± 0.4 4.3 ± 0.3 4.2 ± 0.3 4.2 ± 0.2
  VM 4.3 ± 0.3 4.1 ± 0.2 4.2 ± 0.2 4.2 ± 0.2 4.3 ± 0.2
  PL 4.3 ± 0.2 4.2 ± 0.2 4.3 ± 0.3 4.3 ± 0.3 4.4 ± 0.4
Sodium (mmol/l) IP 139 ± 2 139 ± 2 141 ± 2 140 ± 2 141 ± 2
  VM 139 ± 1 139 ± 2 141 ± 1 140 ± 2 140 ± 1
  PL 138 ± 2 139 ± 1 141 ± 2 140 ± 2 141 ± 2
Chloride (mmol/l) IP 101 ± 2 102 ± 2 103 ± 2 102 ± 2 102 ± 2
  VM 102 ± 2 102 ± 2 104 ± 1 103 ± 2 103 ± 2
  PL 101 ± 2 102 ± 2 104 ± 2 103 ± 2 103 ± 2
Creatinine (mg/dl) IP 0.8 ± 0.1 0.9 ± 0.1 0.8 ± 0.1 0.8 ± 0.1 0.8 ± 0.1
  VM 0.8 ± 0.1 0.8 ± 0.1 0.8 ± 0.1 0.8 ± 0.1 0.8 ± 0.1
  PL 0.8 ± 0.0 0.8 ± 0.1 0.8 ± 0.0 0.8 ± 0.1 0.8 ± 0.1
Urea (mg/dl) IP 26 ± 6. 28 ± 7 28 ± 8* 27 ± 6 28 ± 6
  VM 26 ± 7 28 ± 8 28 ± 7* 29 ± 8 27 ± 7
  PL 30 ± 8 27 ± 6 26 ± 7 29 ± 8 30 ± 7
Uric acid (mg/dl) IP 4.3 ± 1.0 4.5 ± 0.9 4.3 ± 1.1 4.3 ± 1.1 4.6 ± 1.1
  VM 4.2 ± 1.0 4.2 ± 0.8 4.1 ± 0.8 4.2 ± 0.9 4.2 ± 1.0
  PL 4.3 ± 0.9 4.3 ± 1.1 4.3 ± 1.1 4.5 ± 1.3 4.6 ± 1.1
AST (U/l) IP 26 ± 8 25 ± 7 25 ± 9 25 ± 7 26 ± 7
  VM 25 ± 6 23 ± 5 37 ± 60 25 ± 6 25 ± 7
  PL 26 ± 7 24 ± 7 23 ± 6 23 ± 6 26 ± 10
ALT (U/l) IP 20 ± 10 18 ± 7 16 ± 7 16 ± 7 17 ± 8
  VM 20 ± 9 17 ± 6** 20 ± 16 17 ± 8 17 ± 8
  PL 20 ± 10 21 ± 13 19 ± 16 18 ± 14 19 ± 12
Gamma GT (U/l) IP 19 ± 9 18 ± 7 20 ± 9 19 ± 9 19 ± 9
  VM 15 ± 6 15 ± 6 15 ± 5 15 ± 5 14 ± 5
  PL 19 ± 10 20 ± 11 21 ± 12 20 ± 12 18 ± 12
Alkaline phosphatase (U/l) IP 63 ± 20 61 ± 20 64 ± 19 64 ± 18* 63 ± 21
  VM 56 ± 17 56 ± 14 58 ±15 54 ± 12 54 ± 14
  PL 59 ± 14 59 ± 17 58 ±16 57 ± 14 58 ± 19
Bilirubin (mg/dl) IP 0.6 ± 0.2 0.6 ± 0.1 0.6 ± 0.1 0.6 ± 0.1 0.6 ± 0.2
  VM 0.6 ± 0.3 0.7 ± 0.3 0.6 ± 0.3 0.7 ± 0.3* 0.6 ± 0.3
  PL 0.6 ± 0.3 0.6 ± 0.3 0.6 ± 0.5 0.6 ± 0.2 0.6 ± 0.3
Total protein (g/dl) IP 7.7 ± 0.5 7.8 ± 0.4 7.7 ± 0.3 7.8 ± 0.4 7.8 ± 0.6
  VM 7.5 ± 0.3 7.8 ± 0.3 7.6 ± 0.3 7.6 ± 0.3 7.7 ± 0.3
  PL 7.6 ± 0.2 7.7 ± 0.2 7.7 ± 0.3 7.7 ± 0.3 7.6 ± 0.3
Albumin (g/dl) IP 4.7 ± 0.3 4.7 ± 0.2 4.7 ± 0.2 4.7 ± 0.2 4.7 ± 0.3
  VM 4.6 ± 0.2 4.7 ± 0.2 4.7 ± 0.2 4.6 ± 0.2 4.6 ± 0.2
  PL 4.6 ± 0.2 4.7 ± 0.2 4.6 ± 0.3 4.6 ± 0.2 4.5 ± 0.3
Lactate Dehydrogenase (U/l) IP 185 ± 23 179 ± 26 189 ± 36 200 ± 32 189 ± 34
  VM 180 ± 30 172 ± 35 184 ± 78 179 ± 37 184 ± 34
  PL 191 ± 24 186 ± 32 180 ± 29 191 ± 28 197 ± 26
Creatine kinase (U/l) IP 124 ± 78 126 ± 70 149 ± 192 152 ± 113 141 ± 107
  VM 118 ± 89 139 ± 114 657 ± 2556 134 ± 75 127 ± 112
  PL 163 ± 225 140 ± 212 112 ± 83 126 ± 89 197 ± 379
Amylase (U/l) IP 31 ± 8 31 ± 9 30 ± 9 30 ± 8 30 ± 8
  VM 35 ± 11 35 ± 12 34 ± 10 33 ± 11 34 ± 11
  PL 35 ± 9 34 ± 8 34 ± 8 33 ± 7 32 ± 8
Glucose (mg/dl) IP 89 ± 18 81 ± 12* 84 ± 14 82 ± 12 83 ± 13
  VM 89 ± 16 82 ± 10 83 ± 9 85 ± 11 85 ± 16
  PL 81 ± 10 89 ± 18 86 ± 19 85 ± 20 89 ± 15
Cholesterol (mg/dl) IP 178 ± 27 192 ± 26 177 ± 26 176 ± 26 192 ± 29
  VM 178 ± 25 194 ± 32 183 ± 29 185 ± 28 193 ± 26
  PL 191 ± 44 200 ± 48 194 ± 48 192 ± 45 203 ± 43
Triglycerides (mg/dl) IP 116 ± 86 117 ± 68 108 ± 71 121 ± 101 109 ± 73
  VM 86 ± 33 94 ± 38 87 ± 46 87 ± 40 86 ± 32
  PL 123 ± 65 120 ± 52 121 ± 56 110 ± 48 124 ± 66
Thromboplastin time (sec) IP 30 ± 3 nd nd nd 30 ± 3
  VM 30 ± 3 nd nd nd 30 ± 3
  PL 31 ± 3 nd Nd nd 30 ± 4
Prothrombin time (%) IP 106 ± 13 nd nd nd 105 ± 11*
  VM 108 ± 12 nd nd nd 108 ± 10
  PL 107 ± 11 nd nd nd 109 ± 11
  1. IP = Iscucin® Populi, VM = Viscum Mali e planta tota, PL = placebo, nd = not done.
  2. * p < 0.05 compared to placebo, ** p < 0.01 compared to placebo. Significant deviations are bold typed.