Histopathology showing the alterations induced with gentamicin and preventive effects of SAME in hepatic tissues of rat. (A) Hepatic section showing the normal architecture of portal vein (PV) and normal hepatocytes (NH) arranged in trabaculae. (B) Gentamicin (100 mg/kg bw) induced injuries in liver with severe level of leucocytes infiltration (LI) and hydropic degeneration of hepatocytes (HDH). (C) SAME (100 mg/kg bw) prevents injuries of gentamicin; medium level of leucocytes infiltration (LI) and bile ductile (BD). (D) SAME (200 mg/kg bw) prevents injuries of gentamicin; with normal hepatocytes and are arranged in trabaculae.