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Table 4 Adjusteda OR (95% CI) for the association between estrogenic botanical supplement use and hormone-related symptoms during last years of 30-month survey

From: Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report

  Ginseng Red Clover Alfalfa DHEA
  No Yes Adjusteda OR (95% CI) No Yes Adjusteda OR (95% CI) No Yes Adjusteda OR (95% CI) No Yes Adjusteda OR (95% CI)
Hot flashes             
   No 179 19 1.00 191 7 1.00 187 11 1.00 187 11 1.00
   Yes 485 84 1.41 (0.76-2.63) 538 31 0.99 (0.34-2.85) 549 20 0.43 (0.17-1.08) 556 13 0.33 (0.14-0.82)
Vaginal discharge             
   No 427 53 1.00 457 23 1.00 460 20 1.00 466 14 1.00
   Yes 237 50 1.81 (1.12-2.93) 272 15 0.92 (0.42-2.05) 276 11 0.94 (0.41-2.20) 277 10 1.15 (0.48-2.73)
Weight gain             
   No 234 37 1.00 253 18 1.00 257 14 1.00 262 9 1.00
   Yes 430 66 0.94 (0.57-1.55) 476 20 0.41 (0.19-0.91) 479 17 0.76 (0.33-1.76) 481 15 0.88 (0.36-2.11)
Unhappy with bodily appearance             
   No 221 17 1.00 225 13 1.00 226 12 1.00 230 8 1.00
   Yes 443 86 2.58 (1.38-4.81) 504 25 0.49 (0.21-1.17) 510 19 0.67 (0.28-1.60) 513 16 0.76 (0.30-1.93)
Forgetfulness             
   No 147 13 1.00 153 7 1.00 154 6 1.00 156 4 1.00
   Yes 517 90 2.19 (1.11-4.33) 576 31 1.09 (0.40-2.98) 582 25 1.09 (0.39-3.02) 587 20 1.38 (0.43-4.42)
Tendency to take naps, stay in bed             
   No 326 39 1.00 346 19 1.00 352 13 1.00 357 8 1.00
   Yes 338 64 2.24 (1.35-3.72) 383 19 1.20 (0.54-2.70) 384 18 1.37 (0.59-3.18) 386 16 1.96 (0.79-4.87)
Night sweats             
   No 272 31 1.00 285 18 1.00 288 15 1.00 293 10 1.00
   Yes 392 72 1.42 (0.84-2.39) 444 20 0.40 (0.18-0.90) 448 16 0.66 (0.29-1.53) 450 14 0.82 (0.34-1.97)
Difficulty concentrating             
   No 268 34 1.00 282 20 1.00 292 10 1.00 293 9 1.00
   Yes 396 69 1.51 (0.91-2.50) 447 18 0.41 (0.18-0.90) 444 21 1.84 (0.77-4.41) 450 15 1.17 (0.48-2.84)
Interrupted sleeping             
   No 146 18 1.00 154 10 1.00 151 13 1.00 157 7 1.00
   Yes 518 85 1.49 (0.80-2.80) 575 28 0.67 (0.26-1.77) 585 18 0.28 (0.12-0.68) 586 17 0.54 (0.21-1.39)
Irritability or mood swingsb             
   No 270 24 1.00 283 11 1.00 281 13 1.00 282 12 1.00
   Yes 393 79 2.19 (1.26-3.82) 445 27 1.20 (0.51-2.87) 454 18 0.79 (0.34-1.86) 460 12 0.59 (0.24-1.45)
  1. aAdjusted for education, age at diagnosis, medical comorbidity, activity level within the past year of 30-month interview, a combined variable for menopause and hormone therapy, isoflavones from soy-containing foods. In addition, soy supplement, ginseng, flaxseed oil, black cohosh, yam, dong quai, red clover, licorice, alfalfa, DHEA, cat's claw, and other EBS use mutually adjusted. bExcluded one woman with missing information of irritability or mood swings.