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Table 3 The association between estrogenic botanical supplement (EBS) use and total fatigue score

From: Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report

  Association with continuous total fatigue score Association with severe fatigue (≥ 4)
  No. Adjusted regression coefficient (standard error) P value No. with PFS < 4 No. with PFS ≥ 4 Adjusted OR (95% CI)
Ever used EBS after diagnosisa       
   No 464    280 184 1.00
   Yes 303 0.13 (0.17) 0.44 179 124 1.06 (0.78-1.45)
By number of EBS used a       
   1 141 0.11 (0.21) 0.59 86 55 0.98 (0.66-1.46)
   ≥ 2 162 0.14 (0.21) 0.50 93 69 1.14 (0.78-1.69)
By type of EBS used a, b       
   Soy supplements 127 0.07 (0.23) 0.75 75 52 1.16 (0.74-1.80)
   Ginseng 103 0.81 (0.26) 0.002 54 49 1.70 (1.04-2.76)
   Flaxseed oil 100 -0.22 (0.26) 0.40 66 34 0.66 (0.39-1.12)
   Black cohosh 68 -0.17 (0.32) 0.60 43 25 0.78 (0.41-1.46)
   Yam 47 -0.003 (0.37) 0.99 30 17 0.94 (0.45-1.96)
   Dong quai 39 -0.25 (0.40) 0.53 24 15 0.83 (0.38-1.81)
   Red clover 38 -0.60 (0.42) 0.15 26 12 0.52 (0.22-1.21)
   Licorice 37 0.07 (0.40) 0.85 21 16 1.41 (0.65-3.06)
   Alfalfa 31 -0.39 (0.43) 0.36 21 10 0.72 (0.30-1.71)
   Cat's claw 24 0.79 (0.49) 0.11 12 12 2.03 (0.76-5.42)
   DHEA 24 0.27 (0.45) 0.55 11 13 1.96 (0.82-4.70)
   Other EBS 34 -0.57 (0.41) 0.16 22 12 0.79 (0.35-1.77)
  1. aAdjusted for education, age at diagnosis, medical comorbidity, activity level within the past year of 30-month interview, a combined variable for menopause and hormone therapy, isoflavones from soy-containing foods. bAdditionally, all types mutually adjusted.