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Table 2 The association between estrogenic botanical supplement (EBS) use and health-related quality of life (HRQOL) score

From: Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report

 

Association with continuous HRQOL score

Association with better HRQOL (≥ 50)

 

No.

Adjusted regression coefficient (standard error)

P value

No. with low score < 50

No. with high score ≥ 50

Adjusted OR (95% CI)

Association with physical component summary (PCS)

Ever used EBS after diagnosis a

      

   No

464

  

228

236

1.00

   Yes

303

-1.27 (0.67)

0.06

142

161

0.84 (0.60-1.18)

By number of EBS used a

      

   1

141

-1.56 (0.86)

0.07

66

75

0.83 (0.54-1.28)

   ≥ 2

162

-0.99 (0.84)

0.24

76

86

0.85 (0.56-1.28)

By type of EBS used a, b

      

   Soy supplements

127

1.63 (0.93)

0.08

52

75

1.66 (1.02-2.70)

   Ginseng

103

-2.77 (1.04)

0.008

55

48

0.68 (0.40-1.15)

   Flaxseed oil

100

0.41 (1.07)

0.70

41

59

1.20 (0.68-2.09)

   Black cohosh

68

-0.70 (1.31)

0.59

35

33

0.66 (0.35-1.27)

   Yam

47

1.13 (1.51)

0.45

19

28

1.52 (0.70-3.27)

   Dong quai

39

-1.17 (1.65)

0.48

21

18

0.70 (0.31-1.61)

   Red clover

38

-1.40 (1.70)

0.41

22

16

0.61 (0.26-1.41)

   Licorice

37

1.37 (1.62)

0.40

17

20

1.50 (0.64-3.47)

   Alfalfa

31

-0.86 (1.76)

0.62

19

12

0.65 (0.26-1.60)

   Cat's claw

24

-2.38 (2.00)

0.23

13

11

0.80 (0.28-2.28)

   DHEA

24

-1.65 (1.85)

0.37

16

8

0.40 (0.15-1.07)

   Other EBS

34

1.26 (1.67)

0.45

16

18

1.17 (0.50-2.76)

Association with mental component summary (MCS)

Ever used EBS after diagnosis a

      

   No

464

  

200

264

1.00

   Yes

303

0.57 (0.80)

0.48

122

181

1.16 (0.85-1.57)

By number of EBS used a

      

   1

141

0.80 (1.02)

0.43

58

83

1.09 (0.74-1.61)

   ≥ 2

162

0.35 (1.00)

0.73

64

98

1.23 (0.84-1.79)

By type of EBS used a, b

      

   Soy supplements

127

1.06 (1.11)

0.34

44

83

1.42 (0.92-2.20)

   Ginseng

103

-0.80 (1.24)

0.52

44

59

0.88 (0.55-1.42)

   Flaxseed oil

100

2.39 (1.28)

0.06

33

67

1.76 (1.05-2.94)

   Black cohosh

68

-0.50 (1.57)

0.75

28

40

0.94 (0.52-1.73)

   Yam

47

-0.36 (1.81)

0.84

18

29

1.14 (0.56-2.31)

   Dong quai

39

1.28 (1.97)

0.52

16

23

0.98 (0.46-2.11)

   Red clover

38

0.75 (2.04)

0.71

14

24

1.15 (0.51-2.57)

   Licorice

37

-1.09 (1.95)

0.57

16

21

0.79 (0.37-1.67)

   Alfalfa

31

-0.11 (2.10)

0.96

13

18

0.89 (0.40-2.00)

   Cat's claw

24

-3.07 (2.40)

0.20

12

12

0.52 (0.21-1.30)

   DHEA

24

1.49 (2.22)

0.50

10

14

0.93 (0.40-2.21)

   Other EBS

34

0.19 (2.00)

0.93

12

22

1.25 (0.57-2.75)

  1. aAdjusted for education, age at diagnosis, medical comorbidity, activity level within the past year of 30-month interview, a combined variable for menopause and hormone therapy, isoflavones from soy-containing foods. bAdditionally, all types mutually adjusted.