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Table 2 The association between estrogenic botanical supplement (EBS) use and health-related quality of life (HRQOL) score

From: Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report

  Association with continuous HRQOL score Association with better HRQOL (≥ 50)
  No. Adjusted regression coefficient (standard error) P value No. with low score < 50 No. with high score ≥ 50 Adjusted OR (95% CI)
Association with physical component summary (PCS)
Ever used EBS after diagnosis a       
   No 464    228 236 1.00
   Yes 303 -1.27 (0.67) 0.06 142 161 0.84 (0.60-1.18)
By number of EBS used a       
   1 141 -1.56 (0.86) 0.07 66 75 0.83 (0.54-1.28)
   ≥ 2 162 -0.99 (0.84) 0.24 76 86 0.85 (0.56-1.28)
By type of EBS used a, b       
   Soy supplements 127 1.63 (0.93) 0.08 52 75 1.66 (1.02-2.70)
   Ginseng 103 -2.77 (1.04) 0.008 55 48 0.68 (0.40-1.15)
   Flaxseed oil 100 0.41 (1.07) 0.70 41 59 1.20 (0.68-2.09)
   Black cohosh 68 -0.70 (1.31) 0.59 35 33 0.66 (0.35-1.27)
   Yam 47 1.13 (1.51) 0.45 19 28 1.52 (0.70-3.27)
   Dong quai 39 -1.17 (1.65) 0.48 21 18 0.70 (0.31-1.61)
   Red clover 38 -1.40 (1.70) 0.41 22 16 0.61 (0.26-1.41)
   Licorice 37 1.37 (1.62) 0.40 17 20 1.50 (0.64-3.47)
   Alfalfa 31 -0.86 (1.76) 0.62 19 12 0.65 (0.26-1.60)
   Cat's claw 24 -2.38 (2.00) 0.23 13 11 0.80 (0.28-2.28)
   DHEA 24 -1.65 (1.85) 0.37 16 8 0.40 (0.15-1.07)
   Other EBS 34 1.26 (1.67) 0.45 16 18 1.17 (0.50-2.76)
Association with mental component summary (MCS)
Ever used EBS after diagnosis a       
   No 464    200 264 1.00
   Yes 303 0.57 (0.80) 0.48 122 181 1.16 (0.85-1.57)
By number of EBS used a       
   1 141 0.80 (1.02) 0.43 58 83 1.09 (0.74-1.61)
   ≥ 2 162 0.35 (1.00) 0.73 64 98 1.23 (0.84-1.79)
By type of EBS used a, b       
   Soy supplements 127 1.06 (1.11) 0.34 44 83 1.42 (0.92-2.20)
   Ginseng 103 -0.80 (1.24) 0.52 44 59 0.88 (0.55-1.42)
   Flaxseed oil 100 2.39 (1.28) 0.06 33 67 1.76 (1.05-2.94)
   Black cohosh 68 -0.50 (1.57) 0.75 28 40 0.94 (0.52-1.73)
   Yam 47 -0.36 (1.81) 0.84 18 29 1.14 (0.56-2.31)
   Dong quai 39 1.28 (1.97) 0.52 16 23 0.98 (0.46-2.11)
   Red clover 38 0.75 (2.04) 0.71 14 24 1.15 (0.51-2.57)
   Licorice 37 -1.09 (1.95) 0.57 16 21 0.79 (0.37-1.67)
   Alfalfa 31 -0.11 (2.10) 0.96 13 18 0.89 (0.40-2.00)
   Cat's claw 24 -3.07 (2.40) 0.20 12 12 0.52 (0.21-1.30)
   DHEA 24 1.49 (2.22) 0.50 10 14 0.93 (0.40-2.21)
   Other EBS 34 0.19 (2.00) 0.93 12 22 1.25 (0.57-2.75)
  1. aAdjusted for education, age at diagnosis, medical comorbidity, activity level within the past year of 30-month interview, a combined variable for menopause and hormone therapy, isoflavones from soy-containing foods. bAdditionally, all types mutually adjusted.