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Table 3 Effect of RHP and GLGPG on the production of chemokines and cytokines in human PBL

From: Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression

Protein Ratioa LPS/IFN-γ LPS/IFN-γ + RHP (250 mg/L) LPS/IFN-γ + GLGPG (9.7 mg/L)
   pg/mL ± SD pg/mL ± SD p valueb pg/mL ± SD p valueb
Eotaxin 28 84 ± 2 62 ± 6 0.037 62 ± 3 0.013
MCP-1 497 2940 ± 226 4990 ± 71 0.007 1880 ± 368 0.074
MIP-1β 169 90900 ± 1838 109009 ± 1823 0.005 47550 ± 3465 0.004
MIP-1α 2092 21079 ± 1131 27510 ± 849 0.023 10950 ± 71 0.006
IL-8 794 325103 ± 12738 433040 ± 122728 0.059 267052 ± 36770 0.255
CCL5/RANTES 14 4470 ± 57 1011 ± 55 < 0.001 3210 ± 750 0.067
CXCL10/IP-10 47 12650 ± 16 150 ± 16 0.002 5025 ± 148 0.005
IL-1β > 2000 21900 ± 2121 14350 ± 1344 0.051 9195 ± 106 0.014
IL-6 > 2000 79650 ± 4031 68450 ± 4031 0.083 38604 ± 2828 0.005
IL-12(p70) > 200 295 ± 2 19 ± 2 0.002 69 ± 17 0.006
IL-10 67 233 ± 8 382 ± 3 0.002 143 ± 47 0.118
TNF-α > 2000 21107 ± 990 6595 ± 290 0.003 5105 ± 1775 0.008
IFN-γ 672 2065 ± 106 226 ± 18 0.002 475 ± 2 0.002
GM-CSF 158 148 ± 5 190 ± 47 0.329 54 ± 2 0.002
  1. LPS/IFN-γ -stimulated cells were cultured with 31.3 - 1000 mg/L RHP or 1.2 - 38.7 mg/L of GLGPG for 24 h and proteins were quantified by multiparametric analysis (see Materials and Methods). Only the effects of 250 mg/L RHP and 9.7 mg/L GLGPG are shown.
  2. a protein secreted by stimulated/protein secreted by unstimulated cells
  3. b p value = significance value between (LPS/IFN-γ)- and (LPS/IFN-γ + substance) -treatment.