Figure 6
Electron micrographs showing the ultrastructural characteristics of NAm neurons in normal, DM, and DMC-treated DM rats. A: Electron micrograph of cytoplasm from a NAm neuron in a normal rat. The mitochondria (indicated by a hollow arrow) and endoplasmic reticulum (indicated by a solid arrow) are the predominant cytoplasmic organelles. B: Electron micrograph of the cytoplasm from a NAm neuron in a DM rat. The expanded endoplasmic reticulum is circled by a dashed line ellipse, the expanded Golgi body is circled by a solid line, and the partially lysed mitochondrion is indicated by a hollow arrow. C: Electron micrograph of the cytoplasm from a NAm neuron from a DMC-treated DM rat showing regular mitochondrial and endoplasmic reticulum structure. D: Electron micrograph of myelinated nerves from the NAm in a normal rat. Microtubules, microfilaments, and neurofilaments are visible in the medullary sheath and the membranes of myelinated nerves are attached tightly to the inner wall of the medullary sheath. E: Electron micrograph of myelinated nerves from the NAm in a DM rat. Axons appear to detach from the myelin sheath, yielding enlarged paces between the axolemma and medullary sheaths (hollow arrows). Decreased electron density indicates partial dissolution of the axoplasm (* symbol). F: Electron micrograph of myelinated nerves from the NAm a DMC-treated DM rat showing a reduction in the spaces between the axolemma and medullary sheaths (indicated by hollow arrow). Scale bar: 1.0 μm.