Serum AST, U/L (reference range: 10-35 U/L)
|
0.431
|
0.678
|
0.599
|
0.437
|
Baseline
|
19.8 ± 4.3
|
21.2 ± 6.3
|
21.2 ± 5.9
|
19.3 ± 4.3
| | | | |
4 week
|
19.8 ± 4.6
|
20.9 ± 4.8
|
21.4 ± 6.1
|
19.8 ± 4.5
| | | | |
8 week
|
20.5 ± 5.7
|
22.1 ± 6.7
|
21.4 ± 5.8
|
20.8 ± 5.8
| | | | |
12 week
|
19.9 ± 5.1
|
20.9 ± 5.8
|
22.1 ± 7.3
|
20.4 ± 5.1
| | | | |
16 week
|
19.8 ± 4.4
|
22.6 ± 7.4
|
20.9 ± 6.9
|
20.3 ± 5.1
| | | | |
20 week
|
19.3 ± 3.7
|
21.8 ± 6.9
|
22.7 ± 12.3
|
19.3 ± 3.5
| | | | |
24 week
|
19.3 ± 4.2
|
20.2 ± 6.2
|
21.1 ± 7.2
|
20.3 ± 6.1
| | | | |
Serum ALT, U/L (reference range: 6-60 U/L)
|
0.454
|
0.955
|
0.893
|
0.235
|
Baseline
|
16.9 ± 5.5
|
20.4 ± 10.1
|
19.0 ± 7.0
|
18.0 ± 6.9
| | | | |
4 week
|
16.9 ± 4.8
|
19.2 ± 7.9
|
19.5 ± 6.6
|
18.5 ± 7.2
| | | | |
8 week
|
17.4 ± 7.7
|
21.2 ± 10.9
|
20.4 ± 7.8
|
19.2 ± 9.9
| | | | |
12 week
|
17.1 ± 6.4
|
19.9 ± 8.2
|
19.2 ± 9.0
|
19.9 ± 9.1
| | | | |
16 week
|
17.1 ± 5.8
|
21.8 ± 11.7
|
19.7 ± 6.9
|
19.0 ± 8.1
| | | | |
20 week
|
16.6 ± 5.2
|
21.6 ± 11.3
|
20.3 ± 9.4
|
18.1 ± 5.0
| | | | |
24 week
|
16.9 ± 6.3
|
19.1 ± 9.9
|
18.5 ± 5.7
|
19.5 ± 10.2
| | | | |
Serum Bil, mg/dL (reference: 0.2-1.2 mg/dL)
|
0.001
|
0.799
|
0.493
|
0.060
|
Baseline
|
0.58 ± 0.19
|
0.55 ± 0.19
|
0.65 ± 0.25
|
0.64 ± 0.26
| | | | |
4 week
|
0.58 ± 0.23
|
0.59 ± 0.23
|
0.67 ± 0.27
|
0.63 ± 0.22
| | | | |
8 week
|
0.57 ± 0.17
|
0.57 ± 0.21
|
0.68 ± 0.28
|
0.59 ± 0.25
| | | | |
12 week
|
0.58 ± 0.16
|
0.53 ± 0.22
|
0.59 ± 0.30
|
0.60 ± 0.31
| | | | |
16 week
|
0.58 ± 0.18
|
0.54 ± 0.18
|
0.62 ± 0.23
|
0.55 ± 0.22
| | | | |
20 week
|
0.56 ± 0.21
|
0.56 ± 0.23
|
0.64 ± 0.28
|
0.57 ± 0.21
| | | | |
24 week
|
0.56 ± 0.20
|
0.54 ± 0.20
|
0.60 ± 0.17
|
0.56 ± 0.23
| | | | |
Serum ALP, U/L (reference range: 33-130 U/L)
|
< 0.001
|
0.925
|
0.149
|
0.438
|
Baseline
|
75.3 ± 18.6
|
84.1 ± 19.9
|
81.6 ± 20.1
|
86.8 ± 25.2
| | | | |
4 week
|
77.1 ± 17.7
|
85.6 ± 20.5
|
81.5 ± 23.4
|
86.8 ± 23.1
| | | | |
8 week
|
75.2 ± 17.7
|
83.1 ± 22.9
|
85.2 ± 26.0
|
88.6 ± 25.4
| | | | |
12 week
|
75.1 ± 18.0
|
83.2 ± 19.3
|
82.9 ± 24.8
|
87.7 ± 24.2
| | | | |
16 week
|
71.6 ± 18.1
|
84.4 ± 22.2
|
80.8 ± 22.9
|
83.9 ± 21.1
| | | | |
20 week
|
74.7 ± 19.3
|
84.6 ± 20.7
|
83.4 ± 22.1
|
87.0 ± 22.6
| | | | |
24 week
|
72.3 ± 17.3
|
82.5 ± 20.3
|
80.9 ± 22.5
|
83.5 ± 20.7
| | | | |
Serum Crt, mg/dL (reference range: 0.5-1.3 mg/dL)
|
0.001
|
0.230
|
0.605
|
0.884
|
Baseline
|
0.80 ± 0.13
|
0.82 ± 0.11
|
0.78 ± 0.14
|
0.79 ± 0.09
| | | | |
4 week
|
0.82 ± 0.17
|
0.80 ± 0.10
|
0.79 ± 0.13
|
0.79 ± 0.10
| | | | |
8 week
|
0.80 ± 0.13
|
0.80 ± 0.12
|
0.80 ± 0.23
|
0.80 ± 0.11
| | | | |
12 week
|
0.82 ± 0.14
|
0.81 ± 0.11
|
0.80 ± 0.14
|
0.80 ± 0.10
| | | | |
16 week
|
0.81 ± 0.13
|
0.83 ± 0.10
|
0.79 ± 0.13
|
0.82 ± 0.10
| | | | |
20 week
|
0.82 ± 0.14
|
0.82 ± 0.11
|
0.81 ± 0.14
|
0.80 ± 0.11
| | | | |
24 week
|
0.79 ± 0.13
|
0.80 ± 0.11
|
0.77 ± 0.12
|
0.79 ± 0.09
| | | | |
Serum BUN, mg/dL (reference range: 7-25 mg/dL)
|
0.178
|
0.158
|
0.118
|
0.433
|
Baseline
|
15.1 ± 3.1
|
15.8 ± 3.8
|
15.6 ± 4.1
|
15.6 ± 3.7
| | | | |
4 week
|
16.7 ± 4.9
|
15.8 ± 3.4
|
16.4 ± 4.3
|
15.6 ± 4.1
| | | | |
8 week
|
15.8 ± 3.8
|
14.7 ± 3.4
|
15.6 ± 3.7
|
15.6 ± 3.7
| | | | |
12 week
|
16.4 ± 3.4
|
15.4 ± 3.9
|
15.8 ± 4.6
|
15.2 ± 3.5
| | | | |
16 week
|
15.3 ± 3.6
|
15.9 ± 4.0
|
16.7 ± 3.6
|
15.9 ± 3.4
| | | | |
20 week
|
15.9 ± 3.7
|
16.4 ± 3.7
|
15.2 ± 3.5
|
15.3 ± 3.4
| | | | |
24 week
|
15.7 ± 3.7
|
15.7 ± 3.7
|
15.9 ± 5.1
|
15.3 ± 3.5
| | | | |
Serum Ca, mg/dL (reference range: 8.6-10.2 mg/dL)
|
0.005
|
0.721
|
0.076
|
0.883
|
Baseline
|
9.4 ± 0.4
|
9.4 ± 0.3
|
9.4 ± 0.2
|
9.5 ± 0.3
| | | | |
4 week
|
9.5 ± 0.4
|
9.4 ± 0.4
|
9.4 ± 0.3
|
9.4 ± 0.4
| | | | |
8 week
|
9.5 ± 0.5
|
9.4 ± 0.3
|
9.4 ± 0.3
|
9.5 ± 0.4
| | | | |
12 week
|
9.5 ± 0.4
|
9.4 ± 0.5
|
9.4 ± 0.3
|
9.4 ± 0.5
| | | | |
16 week
|
9.4 ± 0.4
|
9.4 ± 0.3
|
9.5 ± 0.4
|
9.5 ± 0.4
| | | | |
20 week
|
9.5 ± 0.4
|
9.3 ± 0.4
|
9.4 ± 0.3
|
9.5 ± 0.3
| | | | |
24 week
|
9.4 ± 0.4
|
9.3 ± 0.3
|
9.3 ± 0.3
|
9.3 ± 0.4
| | | | |
Serum Pi, mg/dL (reference range: 2.5-4.5 mg/dL)
|
0.001
|
0.547
|
0.027
|
0.825
|
Baseline
|
3.7 ± 0.5
|
3.6 ± 0.6
|
3.7 ± 0.5
|
3.7 ± 0.4
| | | | |
4 week
|
3.8 ± 0.5
|
3.6 ± 0.5
|
3.7 ± 0.5
|
3.7 ± 0.5
| | | | |
8 week
|
3.7 ± 0.5
|
3.6 ± 0.5
|
3.8 ± 0.5
|
3.8 ± 0.4
| | | | |
12 week
|
4.0 ± 0.9
|
3.7 ± 0.5
|
3.8 ± 0.5
|
3.8 ± 0.4
| | | | |
16 week
|
3.7 ± 0.5
|
3.7 ± 0.5
|
3.9 ± 0.5
|
3.8 ± 0.5
| | | | |
20 week
|
3.8 ± 0.4
|
3.7 ± 0.5
|
3.8 ± 0.5
|
3.7 ± 0.5
| | | | |
24 week
|
3.7 ± 0.4
|
3.6 ± 0.6
|
3.8 ± 0.5
|
3.7 ± 0.4
| | | | |