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Table 8 Histological effects of the administration of ethanol extracts of D. rotundifolia on rats.

From: Antidiarrhoea and toxicological evaluation of the leaf extract of Dissotis rotundifolia triana (Melastomataceae)

Dosage of administration Histological effect on liver tissues Histological effect on kidney tissues Histological effect on Heart tissues Histological effect on the testes
0. 9 ml of normal saline Tissues appeared normal. No evidence of tissue necrosis Tissues appeared normal. No evidence of tissue necrosis Tissues appeared normal. No evidence of tissue necrosis Tissues appeared normal. No evidence of tissue necrosis
250 mg/kg of D. rotundifolia Densely stained nuclei, increased congestion of the vessels, all of which are evidence of tissue necrosis Tissues appeared normal. No evidence of tissue necrosis Tissues appeared normal. No evidence of tissue necrosis Tissues appeared normal. No evidence of tissue necrosis
500 mg/kg of D. rotundifolia There was increased cytoplasmic eosinophilia and densely stained nuclei. There was also increased congestion of the vessels. These are evidence of liver cell damage. Showed tubular necrosis and degenerative changes in the tubules Tissues appeared normal. No evidence of tissue necrosis Presence of ill defined testes with indistinct cell outlines.