Laxative effects of agarwood on low-fiber diet-induced constipation in rats

Table 3 Effects of EEA and senna on carmine egestion in a rat model of low-fiber diet-induced constipation.

A) Single administration
		Number of rats egesting carmine-containing stools over 1g
Treatments	mg/kg	0-2	2-4	4-6	6-8	8-10	10-12	12-14	14-16	16-18	18-20	20-22	22-24 h
Control		-	-	-	-	-	-	-	1	-	2	2	7
EEA	150	-	-	-	-	-	-	2	-	-	1	5	4
EEA	300	-	-	-	-	-	-	-	1	1	1	7	2
EEA	600*	-	-	-	-	-	4	2	2	2	-	1	1
Senna	150**	-	-	5	3	3	-	1	-	-	-	-	-
Senna	300**	-	1	6	4	1	-	-	-	-	-	-	-
B) Multiple administrations for 14 days
		Number of rats egesting carmine-containing stools over 1g
Treatments	mg/kg	0-2	2-4	4-6	6-8	8-10	10-12	12-14	14-16	16-18	18-20	20-22	22-24 h
Control		-	-	-	-	-	-	-	-	1	-	1	10
EEA	150	-	-	-	-	-	-	1	-	-	3	1	7
EEA	300*	-	-	-	-	-	-	-	3	1	4	-	4
EEA	600**	-	-	-	-	-	1	2	2	3	3	1	-
Senna	150**	-	-	1	3	3	2	1	-	-	-	1	1
Senna	300**	-	5	5	2	-	-	-	-	-	-	-	-

Low-fiber diet-induced constipation was induced in rats by feeding a low fiber diet for 5 weeks. EEA (150, 300, and 600 mg/kg) and senna (150 and 300 mg/kg) were orally administered daily for 14 days, and carmine (10 mg/body) was orally administered to rats just after the administration of the EEA or senna. Effects of single administration of EEA on carmine egestion (A). Effects of multiple oral administrations of EEA on carmine egestion (B). n = 12, **p < 0.01, *p < 0.05 vs. control (Chi-square test).

ISSN: 2662-7671