Curcumin prevents activation of Caspase 3 and inhibits COX-2 in cultured Pods. Representative Western blot analysis of activated Caspase 3 (a) and COX-2 (b) in Pods. 5.5 mM glucose (NG), 5.5 mM glucose+30 μM curcumin (NG+Cur), 30 mM glucose (HG), 30 mM glucose+30 μM curcumin (HG+Cur). Results were normalized with GAPDH. All data expressed as mean ± SEM (n = 3). *P < 0.05 compared with NG; #P < 0.01 compared with NG; ##P < 0.01 compared with HG.