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Table 3 IC50, IC100 and SI of active extracts on the microfilariae of O. ochengi

From: Selective activity of extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi

Extract Mammalian cells Microfilariae Acute toxicity in mice at 5 × IC50 on mfs
  IC50 (μg/mL) IC50 (μg/mL) IC100 (μg/mL) SI  
MRH 93.75 45 62.5 2.08 Non-toxic
MLC 31.25 62.5 125 0.5 Not determined
HLH 250 95 125 2.63 Non-toxic
HLC 46.88 31.25 62.5 1.5 Not determined
  1. SI - Selectivity index. The codes of the extracts are: MRH = hexane extract of M. discoidea roots; MLC = methylene chloride extract of M. discoidea leaves; HLH = hexane extract of H. africanum leaves; HLC = methylene chloride extract H. africanum leaves.