|
Extract
|
Mammalian cells
|
Microfilariae
|
Acute toxicity in mice at 5 × IC50 on mfs
|
|---|
| |
IC50 (μg/mL)
|
IC50 (μg/mL)
|
IC100 (μg/mL)
|
SI
| |
|---|
|
MRH
|
93.75
|
45
|
62.5
|
2.08
|
Non-toxic
|
|
MLC
|
31.25
|
62.5
|
125
|
0.5
|
Not determined
|
|
HLH
|
250
|
95
|
125
|
2.63
|
Non-toxic
|
|
HLC
|
46.88
|
31.25
|
62.5
|
1.5
|
Not determined
|
- SI - Selectivity index. The codes of the extracts are: MRH = hexane extract of M. discoidea roots; MLC = methylene chloride extract of M. discoidea leaves; HLH = hexane extract of H. africanum leaves; HLC = methylene chloride extract H. africanum leaves.
