Antitumor activity against murine lymphoma L5178Y model of proteins from cacao (Theobroma cacao L.) seeds in relation with in vitro antioxidant activity

Table 2 Effect of the protein fractions from UF and SFD cacao Forastero seeds on body weight, tumor volume, packed cell volume, and viable tumor cell count of lymphoma L5178Y mice

Groups	Body weight (g)	Splenomegaly (g)	Tumor volume (mL)	Packed cell volume (mL)	Viable tumor cell count (×10⁶ cells/mL)
Control L5178Y	30.83 ± 2.41	0.23 ± 0.05	2.67 ± 1.08	1.30 ± 0.49	412.62 ± 35.14
L5178Y + Globulin UF	29.32 ± 2.89	0.23 ± 0.11	3.00 ± 1.22	1.12 ± 0.87	286.96 ± 92.84
L5178Y + Glutelin UF	27.5 ± 1.73	0.19 ± 0.02	4.20 ± 0.64 *	1.97 ± 0.60	415.80 ± 92.88
L5178Y + Albumin SFD	28.08 ± 2.38	0.20 ± 0.07	0.60 ± 0.75 *	0.50 ± 0.30 *	750.00 ± 47.03 *
L5178Y + Glutelin SFD	31.06 ± 3.20	0.21 ± 0.01	3.50 ± 3.46	1.02 ± 0.95	365.10 ± 223.82

Non-lethal oral dose of 25 mg/Kg/day during 15 - 17 days, after inoculation of 6 × 10⁴ lymphoma L5178Y cells/mL per mice
Data are expressed as the mean of the results of two experiments with n = 5 in each experiment ± S.E.M.
* p < 0.05 extract-treated groups compared with the lymphoma L5178Y control group
Body weight of normal mice: 23.50 ± 1.59 g. Spleen weight of normal mice: 0.12 ± 0.04 g.

ISSN: 2662-7671