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Table 2 Effect of the protein fractions from UF and SFD cacao Forastero seeds on body weight, tumor volume, packed cell volume, and viable tumor cell count of lymphoma L5178Y mice

From: Antitumor activity against murine lymphoma L5178Y model of proteins from cacao (Theobroma cacao L.) seeds in relation with in vitro antioxidant activity

Groups Body weight (g) Splenomegaly (g) Tumor volume (mL) Packed cell volume (mL) Viable tumor cell count (×106 cells/mL)
Control L5178Y 30.83 ± 2.41 0.23 ± 0.05 2.67 ± 1.08 1.30 ± 0.49 412.62 ± 35.14
L5178Y + Globulin UF 29.32 ± 2.89 0.23 ± 0.11 3.00 ± 1.22 1.12 ± 0.87 286.96 ± 92.84
L5178Y + Glutelin UF 27.5 ± 1.73 0.19 ± 0.02 4.20 ± 0.64 * 1.97 ± 0.60 415.80 ± 92.88
L5178Y + Albumin SFD 28.08 ± 2.38 0.20 ± 0.07 0.60 ± 0.75 * 0.50 ± 0.30 * 750.00 ± 47.03 *
L5178Y + Glutelin SFD 31.06 ± 3.20 0.21 ± 0.01 3.50 ± 3.46 1.02 ± 0.95 365.10 ± 223.82
  1. Non-lethal oral dose of 25 mg/Kg/day during 15 - 17 days, after inoculation of 6 × 104 lymphoma L5178Y cells/mL per mice
  2. Data are expressed as the mean of the results of two experiments with n = 5 in each experiment ± S.E.M.
  3. * p < 0.05 extract-treated groups compared with the lymphoma L5178Y control group
  4. Body weight of normal mice: 23.50 ± 1.59 g. Spleen weight of normal mice: 0.12 ± 0.04 g.