Figure 4

Concentration-response curves showing the vasodilator effect of Mc.Cr (A) and verapamil (B) in the absence and presence of the N _ω -nitro-l-arginine methyl ester (L-NAME, 0.1 mM) and atropine (1 μM) and on phenylephrine (PE 1 μM) induced contractions in isolated endothelium-intact and denude rat aorta preparations. **P < 0.01; ***P < 0.001; shows a comparison of concentration-dependent effects(specified effect compared with the effect of preceding dose) on endothelial intact rat aorta, whereas, ^ωωωP < 0.001; shows a comparison of concentration-dependent effect on endothelial denuded rat aorta and ^æææP < 0.001; shows a comparison of concentration-dependent effect on L-NAME with endothelial intact rat aorta, ^###P < 0.001; shows a comparison of concentration-dependent effect on atropine pre-treatment with endothelial intact rat aorta.