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Table 3 Frequency distribution of Chromosome Aberrations (CA) in 500 bone marrow cells examined (100 cells from each individuals).

From: Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study

   

Mitotic Index

Chromosome Aberration

Micronucleated Erythrocyte

Sperm Head Anomaly

Intervals (hr)

Drug potency

 

% ± SE

% of Increased MI.

% of Major CA

% of Other CA

% of Total CA ± SE

% of Prot.

% of MN in NCE

% of MN in PCE

P/N

% of Total MN in NCE & PCE

% of Prot.

% of SHA ± SE

% of prot.

6

30

T5

1.84 ± 0.22

 

3.4

5.4

8.8 ± 1.14

 

0.15

0.58

0.11

0.21 ± 0.02

 

1.6 ± 0.15

 
  

C5

1.42 ± 0.14

0.42

4.4

6

10.4 ± 1.82

1.6

0.31

0.72

0.33

0.41 ± 0.04

0.20a

1.64 ± 0.07

0.04

 

200

T6

2.1 ± 0.25

 

2

3

5 ± 1.17

 

0.14

0.7

0.24

0.22 ± 0.05

 

1.72 ± 0.17

 
  

C6

1.48 ± 0.16

0.62

4.2

4.6

10.8 ± 1.14

5.8

0.33

1.06

0.51

0.48 ± 0.05

0.26b

1.5 ± 0.12

-0.22

12

30

T5

2.24 ± 0.12

 

4.8

6.4

11.2 ± 0.65

 

0.16

0.59

0.20

0.27 ± 0.02

 

1.7 ± 0.22

 
  

C5

1.56 ± 0.13

0.68b

8

9.4

17.4 ± 1.68

6.2b

0.43

0.77

0.49

0.55 ± 0.05

0.32c

2.16 ± 0.28

0.46a

 

200

T6

2.42 ± 0.12

 

3

4.8

7.4 ± 0.74

 

0.14

0.38

0.18

0.17 ± 0.02

 

1.52 ± 0.19

 
  

C6

1.46 ± 0.13

0.96c

5.8

10.2

16 ± 1.54

8.2c

0.36

0.81

0.45

0.51 ± 0.04

0.34c

2.12 ± 0.21

0.6

24

30

T5

2.04 ± 0.18

 

6.0

6.6

12.6 ± 1.2

 

0.31

1

0.31

0.47 ± 0.04

 

3.02 ± 0.19

 
  

C5

1.1 ± 0.20

0.94b

14.6

15.6

30.2 ± 1.63

17.6c

0.91

1.81

0.32

1.12 ± 0.08

0.77c

5.09 ± 0.30

2.07c

 

200

T6

2.28 ± 0.26

 

4.8

5.6

10.4 ± 1.30

 

0.18

0.47

0.32

0.25 ± 0.02

 

2.64 ± 0.23

 
  

C6

0.98 ± 0.17

1.3b

13.4

18.4

31.8 ± 1.55

21.4c

0.87

1.72

0.30

1.05 ± 0.10

0.80c

4.96 ± 0.57

2.32b

48

30

T5

2.44 ± 0.09

 

5.6

5.8

11.4 ± 1.03

 

0.36

0.53

0.51

0.41 ± 0.06

 

3.64 ± 0.29

 
  

C5

1.44 ± 0.20

1b

12.4

13.6

26 ± 1.87

14.6c

0.98

1.63

0.46

1.20 ± 0.04

0.79

5.64 ± 0.34

2b

 

200

T6

2.84 ± 0.16

 

5.0

5.8

10.8 ± 1.14

 

0.12

0.44

0.55

0.23 ± 0.02

 

3.38 ± 0.35

 
  

C6

1.16 ± 0.13

1.68c

13.0

14

27 ± 1.11

16.2c

1.06

1.56

0.49

1.22 ± 0.05

0.99c

5.74 ± 0.32

2.36b

72

30

T5

2.86 ± 0.14

 

3.2

5.6

8.8 ± 1.14

 

0.7

1.23

0.46

0.89 ± 0.09

 

4.72 ± 0.23

 
  

C5

1.68 ± 0.09

1.18c

8.0

9.4

17.4 ± 1.51

8.6c

1.21

1.64

0.57

1.38 ± 0.04

0.49c

7.06 ± 0.24

2.34c

 

200

T6

3.18 ± 0.28

 

3.6

4.8

8.4 ± 1.33

 

0.12

0.55

0.27

0.21 ± 0.04

 

5.38 ± 0.20

 
  

C6

1.6 ± 0.09

1.58c

9.0

12.4

21.4 ± 1.30

13c

1.45

0.64

0.64

1.38 ± 0.09

1.17c

7.96 ± 0.35

2.58c

96

30

T5

2.68 ± 0.24

 

3.8

4.8

8.6 ± 0.90

 

0.27

0.69

0.29

0.37 ± 0.02

 

2.18 ± 0.15

 
  

C5

1.68 ± 0.13

1.00b

9.2

10

19.2 ± 1.55

10.6c

1.18

1.34

0.46

1.20 ± 0.04

0.83c

4.88 ± 0.30

2.7c

 

200

T6

3 ± 0.23

 

3.6

4.4

8 ± 0.61

 

0.15

0.29

0.29

0.23 ± 0.02

 

1.86 ± 0.13

 
  

C6

1.58 ± 0.13

1.42b

9.0

9.8

18.8 ± 1.31

10.8c

1.06

0.45

0.45

1.10 ± 0.07

0.87c

5.02 ± 0.14

3.16c

  1. a = p < 0.05, b = p < 0.01, c = p < 0.001 (significance levels of t-test) Mitotic Indices (MI) in 5000 cells (1000 cells from each individuals), Micronuclei in normochromatic erythrocytes (NCE) and polychromatic erythrocytes (PCE) in 5000 cells (1000 cells from each individuals) and Sperm head-shape abnormality (SHA) in 5000 sperm (1000 sperm from each individuals) at different fixation intervals in CdCl2 treated mice combined pre- and post-fed with Cad Sulph-30 (T5) and Cad Sulph-200 (T6) separately and respective alcohol-30 (C5) and alcohol-200 (C6) fed controls.
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BMC Complementary Medicine and Therapies

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