|  |  | Mitotic Index | Chromosome Aberration | Micronucleated Erythrocyte | Sperm Head Anomaly | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Intervals (hr) | Drug potency | Series | % ± SE | % of Increased MI | % of Major CA | % of Other CA | Total CA ± SE | Prot. | % of MN in NCE | % of MN in PCE | P/N | % of Total MN in NCE & PCE | % of Prot, | % of SHA ± SE | % of prot. |
6 | 30 | T3 | 1.72 ± 0.18 |  | 3.2 | 6 | 9.2 ± 0.82 |  | 0.15 | 1.07 | 0.12 | 0.25 ± 0.04 |  | 1.62 ± 0.20 |  |
 |  | C3 | 1.84 ± 0.20 | -0.12 | 3.8 | 7.4 | 11.2 ± 0.96 | 2.0 | 0.23 | 0.73 | 0.32 | 0.35 ± 0.02 | 0.10a | 1.68 ± 0.25 | 0.06 |
 | 200 | T4 | 1.98 ± 0.23 |  | 3.4 | 5.2 | 8.6 ± 1.20 |  | 0.2 | 0.67 | 0.13 | 0.25 ± 0.04 |  | 1.48 ± 0.19 |  |
 |  | C4 | 1.6 ± 0.18 | 0.38 | 5 | 6.6 | 11.6 ± 1.44 | 3.0 | 0.23 | 0.51 | 0.30 | 0.29 ± 0.03 | 0.04a | 1.56 ± 0.18 | 0.08 |
12 | 30 | T3 | 1.84 ± 0.14 |  | 6 | 6.8 | 12.8 ± 0.82 |  | 0.2 | 0.58 | 0.25 | 0.27 ± 0.04 |  | 1.64 ± 0.18 |  |
 |  | C3 | 1,36 ± 0,17 | 0.48 | 7.6 | 9.8 | 17.4 ± 1.44 | 4.6a | 0.43 | 0.64 | 0.45 | 0.49 ± 0.05 | 0.22a | 2.12 ± 0.26 | 0.48 |
 | 200 | T4 | 2.08 ± 0.14 |  | 4.8 | 4.8 | 9.6 ± 1.03 |  | 0.17 | 0.41 | 0.23 | 0.21 ± 0.02 |  | 1.32 ± 0.16 |  |
 |  | C4 | 1.38 ± 0.19 | 0.7a | 6.8 | 9.8 | 16.6 ± 1.60 | 7.0a | 0.4 | 0.57 | 0.45 | 0.47 ± 0.06 | 0.26a | 2.04 ± 0.23 | 0.72a |
24 | 30 | t3 | 1.7 ± 0.33 |  | 8.2 | 9.4 | 17.6 ± 1.52 |  | 0.54 | 1 | 0.31 | 0.65 ± 0.05 |  | 3.6 ± 0.24 |  |
 |  | C3 | 1.1 ± 0.21 | 0.6 | 15.2 | 14.6 | 29.8 ± 1.55 | 12.2c | 0.81 | 1.44 | 0.28 | 0.95 ± 0.08 | 0.30a | 4.98 ± 0.28 | 1.38b |
 | 200 | T4 | 1.88 ± 0.35 |  | 6.6 | 6.6 | 13.2 ± 2.07 |  | 0.36 | 0.62 | 0.40 | 0.43 ± 0.04 |  | 3.1 ± 0.24 |  |
 |  | C4 | 0.98 ± 0.22 | 0.9 | 16.4 | 14.2 | 30.6 ± 1.56 | 17.4c | 0.86 | 1.69 | 0.28 | 1.05 ± 0.07 | 0.62c | 5.12 ± 0.28 | 2.02c |
48 | 30 | t3 | 2 ± 0.16 |  | 7.8 | 9 | 16.8 ± 0.77 |  | 0.54 | 0.76 | 0.45 | 0.61 ± 0.08 |  | 4.56 ± 0.39 |  |
 |  | C3 | 0.98 ± 0.14 | 1.02b | 11 | 12.8 | 23.8 ± 1.34 | 7.0b | 1.34 | 1.28 | 0.54 | 1.32 ± 0.08 | 0.71c | 5.9 ± 0.41 | 1.34a |
 | 200 | T4 | 2.34 ± 0.16 |  | 7 | 7.4 | 14.4 ± 0.90 |  | 0.32 | 0.41 | 0.50 | 0.35 ± 0.02 |  | 4.06 ± 0.39 |  |
 |  | C4 | 1.06 ± 0.13 | 1.28c | 12 | 13.8 | 25.8 ± 0.96 | 11.4c | 1.15 | 1.41 | 0.50 | 1.22 ± 0.04 | 0.87c | 6.02 ± 0.38 | 1.96b |
72 | 30 | t3 | 2.76 ± 0.21 |  | 5.6 | 7.2 | 12.8 ± 1.38 |  | 0.47 | 0.64 | 0.33 | 0.51 ± 0.06 |  | 7.64 ± 0.16 |  |
 |  | C3 | 1.7 ± 0.18 | 1.06b | 9.6 | 10.4 | 20 ± 1.45 | 7.2b | 1.65 | 1.06 | 0.58 | 1.44 ± 0.09 | 0.93c | 7.74 ± 0.30 | 0.10 |
 | 200 | T4 | 2.9 ± 0.22 |  | 6.6 | 4.4 | 11 ± 1.50 |  | 0.26 | 0.59 | 0.30 | 0.33 ± 0.05 |  | 4.86 ± 0.33 |  |
 |  | C4 | 1.56 ± 0.07 | 1.34c | 9.4 | 11.2 | 20.6 ± 1.64 | 9.6c | 1.17 | 1.62 | 0.60 | 1.32 ± 0.08 | 0.99c | 7.28 ± 0.20 | 2.42c |
96 | 30 | t3 | 2.3 ± 0.23 |  | 4.6 | 7.6 | 12.2 ± 1.14 |  | 0.28 | 0.92 | 0.17 | 0.37 ± 0.06 |  | 2.72 ± 0.18 |  |
 |  | C3 | 1.26 ± 0.15 | 1.04c | 8.2 | 10.2 | 18.4 ± 1.60 | 6.2a | 0.86 | 0.94 | 0.49 | 0.91 ± 0.09 | 0.54c | 4.64 ± 0.34 | 1.92b |
 | 200 | T4 | 2.56 ± 0.26 |  | 3.2 | 5.6 | 9.8 ± 1.24 |  | 0.18 | 0.71 | 0.16 | 0.25 ± 0.02 |  | 2.38 ± 0.24 |  |
 |  | C4 | 1.42 ± 0.10 | 1.14b | 7.4 | 10.4 | 17.6 ± 1.60 | 7.8b | 0.94 | 1.01 | 0.49 | 0.97 ± 0.09 | 0.72c | 5.14 ± 0.19 | 2.76c |