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Table 1 Frequency distribution of Chromosome Aberrations (CA) in 500 bone marrow cells examined (100 cells from each individuals).

From: Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study

   

Mitotic Index

Chromosome Aberration

Micronucleated Erythrocyte

Sperm Head Anomaly

Fixation Intervals (hr)

Drug potency

Series

% ± SE

% of Increased MI

% of Major CA

% of Other CA

% of Total CA ± SE

% of Prot.

% of MN in NCE

% of MN in PCE

P/N

% of Total MN in NCE & PCE

% of Prot.

% of SHA ± SE

% of prot.

6

30

T1

1.52 ± 0.20

 

5.4

6.2

11.6 ± 1.60

 

0.25

0.99

0.16

0.35 ± 0.04

 

1.72 ± 0.13

 
  

C1

1.34 ± 0.17

0.18

5.6

4.4

10 ± 1.45

-1.6

0.24

0.78

0.28

0.41 ± 0.04

0.06

1.62 ± 0.12

-0.1

 

200

 

1.72 ± 0.02

 

4.6

6

10.6 ± 1.44

 

0.18

1.26

0.16

0.33 ± 0.06

 

1.74 ± 0.09

 
  

C2

1.66 ± 0.16

0.06

4,8

5.8

10.6 ± 1.44

0

0.26

0.76

0.30

0.37 ± 0.04

0.04

1.56 ± 0.23

-0.18

12

30

T1

1.68 ± 0.11

 

6.8

8.4

15.2 ± 1.08

 

0.23

0.71

0.03

0.33 ± 0.05

 

1.86 ± 0.13

 
  

C1

1.38 ± 0.12

0.3

8

8.4

16.4 ± 1.75

1.2

0.4

0.6

0.47

0.47 ± 0.04

0.14a

2.04 ± 0.20

0.18

 

200

T2

1.88 ± 0.11

 

4.4

7.2

11.6 ± 1.03

 

0.25

0.77

0.30

0.37 ± 0.04

 

1.80 ± 0.15

 
  

C2

1.44 ± 0.19

0.44

6.8

8.4

15.2 ± 1.55

3.6

0.51

0.7

0.44

0.57 ± 0.06

0.20a

1.96 ± 0.25

0.16

24

30

T1

1.68 ± 0.38

 

9.4

13.4

22.8 ± 1.98

 

0.46

1.22

0.38

0.67 ± 0.06

 

4.40 ± 0.30

 
  

C1

1.04 ± 0.21

0.64a

15.6

13.9

29.4 ± 2.28

6.6

0.84

1.68

0.28

1.03 ± 0.07

0.36b

4.94 ± 0.29

0.54

 

200

T2

1.84 ± 0.37

 

8.2

7.6

15.8 ± 1.94

 

0.59

1.33

0.33

0.73 ± 0.05

 

4.24 ± 0.30

 
  

C2

1.11 ± 0.17

0.74

14.8

13.4

28.2 ± 1.47

12.4c

0.8

1.51

0.30

0.97 ± 0.10

0.24

4.74 ± 0.21

0.5

48

30

T1

1.86 ± 0.13

 

8.6

10.2

18,80,96

 

0.84

1.34

0.48

1.01 ± 0.08

 

5.24 ± 0.38

 
  

C1

1.44 ± 0.17

0.42

12.6

12.4

25 ± 1.36

6.2b

1.25

1.54

0.44

1.34 ± 0.12

0.33a

5.62 ± 0.31

0.38

 

200

T2

2.04 ± 0.13

 

8.6

7.8

16.4 ± 1.09

 

0.87

1.5

0.51

1.07 ± 0.07

 

5.08 ± 0.38

 
  

C2

1.42 ± 0.23

0.62

12.4

12

24.4 ± 0.96

8c

1.32

1.44

0.48

1.32 ± 0.11

0.25

5.68 ± 0.44

0.6

72

30

T1

2.28 ± 0.18

 

7.6

8.6

16.2 ± 0.89

 

0.7

1.23

0.45

0.89 ± 0.09

 

6.18 ± 0.10

 
  

C1

1.52 ± 0.10

0.76b

10

11

21 ± 1.45

4.8a

1.21

1.64

0.62

1.38 ± 0.04

0.49c

7.02 ± 0.20

0.84b

 

200

T2

2.5 ± 0.20

 

5.8

6.6

12.4 ± 1.81

 

0.64

1.24

0.40

0.83 ± 0.13

 

6.16 ± 0.24

 
  

C2

1.86 ± 0.23

0.64

9.8

9.6

19.4 ± 1.48

7b

1.5

1.16

0.59

1.38 ± 0.13

0.55a

6.98 ± 0.30

0.82

96

30

T1

1.98 ± 0.20

 

6

9.2

15.2 ± 0.65

 

0.44

1.22

0.32

0.63 ± 0.05

 

3.62 ± 0.54

 
  

C1

1.64 ± 0.16

0.34

9.4

9

18.4 ± 1.44

3.2

1.01

1.11

0.51

1.03 ± 0.08

0.40b

4.68 ± 0.60

1.06

 

200

T2

2.2 ± 0.22

 

5.

7

12 ± 2.44

 

0.39

0.95

0.33

0.53 ± 0.04

 

3.80 ± 0.29

 
  

C2

1.48 ± 0.10

0.72a

8.2

8.2

16.6 ± 1.15

4.6

0.91

0.96

0.53

0.93 ± 0.11

0.40b

5.12 ± 0.10

1.32b

  1. a = p < 0.05, b = p < 0.01, c = p < 0.001 (significance levels of t-test) Mitotic Indices (MI) in 5000 cells (1000 cells from each individuals), Micronuclei in normochromatic erythrocytes (NCE) and polychromatic erythrocytes (PCE) in 5000 cells (1000 cells from each individuals) and Sperm head-shape abnormality (SHA) in 5000 sperm (1000 sperm from each individuals) at different fixation intervals in CdCl2 treated mice pre-fed with Cad Sulph-30 (T1) and Cad Sulph-200 (T2) separately and respective alcohol-30 (C1) and alcohol-200 (C2) fed controls.