|  |  | Mitotic Index | Chromosome Aberration | Micronucleated Erythrocyte | Sperm Head Anomaly | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fixation Intervals (hr) | Drug potency | Series | % ± SE | % of Increased MI | % of Major CA | % of Other CA | % of Total CA ± SE | % of Prot. | % of MN in NCE | % of MN in PCE | P/N | % of Total MN in NCE & PCE | % of Prot. | % of SHA ± SE | % of prot. |
6 | 30 | T1 | 1.52 ± 0.20 |  | 5.4 | 6.2 | 11.6 ± 1.60 |  | 0.25 | 0.99 | 0.16 | 0.35 ± 0.04 |  | 1.72 ± 0.13 |  |
 |  | C1 | 1.34 ± 0.17 | 0.18 | 5.6 | 4.4 | 10 ± 1.45 | -1.6 | 0.24 | 0.78 | 0.28 | 0.41 ± 0.04 | 0.06 | 1.62 ± 0.12 | -0.1 |
 | 200 |  | 1.72 ± 0.02 |  | 4.6 | 6 | 10.6 ± 1.44 |  | 0.18 | 1.26 | 0.16 | 0.33 ± 0.06 |  | 1.74 ± 0.09 |  |
 |  | C2 | 1.66 ± 0.16 | 0.06 | 4,8 | 5.8 | 10.6 ± 1.44 | 0 | 0.26 | 0.76 | 0.30 | 0.37 ± 0.04 | 0.04 | 1.56 ± 0.23 | -0.18 |
12 | 30 | T1 | 1.68 ± 0.11 |  | 6.8 | 8.4 | 15.2 ± 1.08 |  | 0.23 | 0.71 | 0.03 | 0.33 ± 0.05 |  | 1.86 ± 0.13 |  |
 |  | C1 | 1.38 ± 0.12 | 0.3 | 8 | 8.4 | 16.4 ± 1.75 | 1.2 | 0.4 | 0.6 | 0.47 | 0.47 ± 0.04 | 0.14a | 2.04 ± 0.20 | 0.18 |
 | 200 | T2 | 1.88 ± 0.11 |  | 4.4 | 7.2 | 11.6 ± 1.03 |  | 0.25 | 0.77 | 0.30 | 0.37 ± 0.04 |  | 1.80 ± 0.15 |  |
 |  | C2 | 1.44 ± 0.19 | 0.44 | 6.8 | 8.4 | 15.2 ± 1.55 | 3.6 | 0.51 | 0.7 | 0.44 | 0.57 ± 0.06 | 0.20a | 1.96 ± 0.25 | 0.16 |
24 | 30 | T1 | 1.68 ± 0.38 |  | 9.4 | 13.4 | 22.8 ± 1.98 |  | 0.46 | 1.22 | 0.38 | 0.67 ± 0.06 |  | 4.40 ± 0.30 |  |
 |  | C1 | 1.04 ± 0.21 | 0.64a | 15.6 | 13.9 | 29.4 ± 2.28 | 6.6 | 0.84 | 1.68 | 0.28 | 1.03 ± 0.07 | 0.36b | 4.94 ± 0.29 | 0.54 |
 | 200 | T2 | 1.84 ± 0.37 |  | 8.2 | 7.6 | 15.8 ± 1.94 |  | 0.59 | 1.33 | 0.33 | 0.73 ± 0.05 |  | 4.24 ± 0.30 |  |
 |  | C2 | 1.11 ± 0.17 | 0.74 | 14.8 | 13.4 | 28.2 ± 1.47 | 12.4c | 0.8 | 1.51 | 0.30 | 0.97 ± 0.10 | 0.24 | 4.74 ± 0.21 | 0.5 |
48 | 30 | T1 | 1.86 ± 0.13 |  | 8.6 | 10.2 | 18,80,96 |  | 0.84 | 1.34 | 0.48 | 1.01 ± 0.08 |  | 5.24 ± 0.38 |  |
 |  | C1 | 1.44 ± 0.17 | 0.42 | 12.6 | 12.4 | 25 ± 1.36 | 6.2b | 1.25 | 1.54 | 0.44 | 1.34 ± 0.12 | 0.33a | 5.62 ± 0.31 | 0.38 |
 | 200 | T2 | 2.04 ± 0.13 |  | 8.6 | 7.8 | 16.4 ± 1.09 |  | 0.87 | 1.5 | 0.51 | 1.07 ± 0.07 |  | 5.08 ± 0.38 |  |
 |  | C2 | 1.42 ± 0.23 | 0.62 | 12.4 | 12 | 24.4 ± 0.96 | 8c | 1.32 | 1.44 | 0.48 | 1.32 ± 0.11 | 0.25 | 5.68 ± 0.44 | 0.6 |
72 | 30 | T1 | 2.28 ± 0.18 |  | 7.6 | 8.6 | 16.2 ± 0.89 |  | 0.7 | 1.23 | 0.45 | 0.89 ± 0.09 |  | 6.18 ± 0.10 |  |
 |  | C1 | 1.52 ± 0.10 | 0.76b | 10 | 11 | 21 ± 1.45 | 4.8a | 1.21 | 1.64 | 0.62 | 1.38 ± 0.04 | 0.49c | 7.02 ± 0.20 | 0.84b |
 | 200 | T2 | 2.5 ± 0.20 |  | 5.8 | 6.6 | 12.4 ± 1.81 |  | 0.64 | 1.24 | 0.40 | 0.83 ± 0.13 |  | 6.16 ± 0.24 |  |
 |  | C2 | 1.86 ± 0.23 | 0.64 | 9.8 | 9.6 | 19.4 ± 1.48 | 7b | 1.5 | 1.16 | 0.59 | 1.38 ± 0.13 | 0.55a | 6.98 ± 0.30 | 0.82 |
96 | 30 | T1 | 1.98 ± 0.20 |  | 6 | 9.2 | 15.2 ± 0.65 |  | 0.44 | 1.22 | 0.32 | 0.63 ± 0.05 |  | 3.62 ± 0.54 |  |
 |  | C1 | 1.64 ± 0.16 | 0.34 | 9.4 | 9 | 18.4 ± 1.44 | 3.2 | 1.01 | 1.11 | 0.51 | 1.03 ± 0.08 | 0.40b | 4.68 ± 0.60 | 1.06 |
 | 200 | T2 | 2.2 ± 0.22 |  | 5. | 7 | 12 ± 2.44 |  | 0.39 | 0.95 | 0.33 | 0.53 ± 0.04 |  | 3.80 ± 0.29 |  |
 |  | C2 | 1.48 ± 0.10 | 0.72a | 8.2 | 8.2 | 16.6 ± 1.15 | 4.6 | 0.91 | 0.96 | 0.53 | 0.93 ± 0.11 | 0.40b | 5.12 ± 0.10 | 1.32b |